EFFECT OF FAST ROTATING-LONG RETAINING ACUPUNCTURE THERAPY ON CEREBRAL CONTENTS OF GLUTAMIC ACID AND GAMMA-AMINOBUTYRIC ACID IN VESTIBULE NUCLEUS OF RATS WITH POSTERIOR CIRCULATION ISCHEMIC VERTIGO

Meng Ling-Jie¹, Zhu Xiao-Han¹, Dong Yong-Shu^2*, Niu Lin¹

¹Department of medical technology, Zhengzhou Railway Vocational and Technical College, Zhengzhou, China - ²Henan Provincial Academy of Traditional Chinese Medicine, Zhengzhou, China 450004

Objective: This study is to investigate the effects of Fast rotating-Long retaining Acupuncture Therapy on cerebral Contents of Glutamic Acid and Gamma-aminobutyric Acid in Vestibule nucleus of Rats with Posterior circulation ischemic vertigo.

Method: The rats with Posterior circulation ischemic vertigo were randomly divided into model group(M), common acupuncture group(CA), Fast rotating-Long retaining Acupuncture method group(FRA),and sham operation group(SO). The two acupuncture group selected "Baihui acupoint", "Shuaigu acupoint " and "Fengchi acupoint " treatment, 1 times a day. One group was given conventional acupuncture and another was given Fast rotating-Long retaining Acupuncture Method treatment.The treatment must last 10 days. After 10 days, the rats were killed and the contents of glutamic acid and gamma-aminobutyric acid were measured. 

Result: Compared with sham operation, Glu levels in model group were significantly higer(P<0.01),while GABA levels significantly lower (P<0.01). Compared with model group,Glu levels in common acupuncture group were lower(P<0.05), and GABA levels in common acupuncture group were higer(P<0.05); GLU levels in Fast rotating-Long retaining acupuncture method group were significantly lower(P<0.01), GABA levels were significantly higer(P<0.01).     

Conclusion: The fast rotating-Long retaining acupuncture method can alleviate the "excitability toxicity" after ischemia, regulate the content of GLU and GABA, so as to improve the cerebral ischemia state and alleviate the vertigo symptoms.