CORRELATION OF HEMORHEOLOGICAL INDEXES, SERUM HCY, CAT S AND HS-CRP WITH THE DEGREE OF CAROTID ARTERY STENOSIS IN PATIENTS WITH ISCHEMIC CEREBROVASCULAR DISEASE

Chuanzhen Qiu^*, Bangming Guo, Yian Ouyang, Shunde Hua, Haibin Wang, Wei Cheng 

Department of Neurosurgery, the First Affiliated Hospital of Gannan Medical University

Objective: To explore the correlation between hemorheology indexes, serum Hcy, CatS and hs-CRP and the degree of carotid artery stenosis in patients with ischemic cerebrovascular disease. 

Methods: A total of 89 patients with ischemic cerebrovascular disease treated in our hospital from May 2017 to April 2019 were recruited as the observation group, and 50 adults who received a physical examination in our hospital during the same period were selected as the control group. Patients in the observation group were divided into different subgroups according to the degree of carotid artery stenosis (52 cases in the mild stenosis group, 24 cases in the moderate stenosis group, 13 cases in the severe stenosis group), plaque nature (35 cases in the hard plaque group, 30 cases in the other types group, 24 cases in the soft plaque group), and carotid artery intima-media thickness (29 cases in the intimal thickening group, 60 cases in the plaque formation group). The whole blood viscosity, plasma viscosity, Hcy, CatS, and hs-CRP levels were compared between each subgroup, and the correlation between these indicators and the degree of carotid artery stenosis, plaque properties, and intima-media thickness was further analyzed. 

Results: The levels of hs-CRP, Hcy, CatS, whole blood viscosity and plasma viscosity were significantly higher in different stenosis groups than levels in the control group (P<0.05). The levels of hs-CRP, Hcy, CatS, whole blood viscosity and plasma viscosity in the severe stenosis group and the moderate stenosis group were significantly higher than those in mild stenosis group (P<0.05), while the levels in the severe stenosis group were significantly higher than those in the moderate stenosis group (P<0.05). The levels of hs-CRP, Hcy, CatS, whole blood viscosity, and plasma viscosity were significantly higher in the various plaque groups compared to the control group (P<0.05), while the levels of hs-CRP, Hcy, CatS, whole blood viscosity, and plasma viscosity in the other type groups and soft plaque groups were significantly higher compared to the hard plaque groups (P<0.05). The levels of hs-CRP, Hcy, CatS, whole blood viscosity, and plasma viscosity in the soft plaque group were significantly higher than those in other types of groups (P<0.05). Additionally, the levels of hs-CRP, Hcy, CatS, whole blood viscosity and plasma viscosity were significantly higher in the intimal thickening group and plaque formation group than in the control group (P<0.05); the levels in the plaque formation group were significantly higher than those in the intimal thickening group (P<0.05). Lastly, the whole blood viscosity, plasma viscosity, Hcy, CatS, and hs-CRP of patients with ischemic cerebrovascular disease were positively correlated with carotid artery stenosis, plaque properties, and intima-media thickness (P<0.05). 

Conclusion: Serum whole blood viscosity, plasma viscosity, Hcy, CatS, and hs-CRP are all involved in the onset and progression of ischemic cerebrovascular disease and are positively correlated with the degree of carotid artery stenosis, plaque properties, and intima-media thickness. This study demonstrates that these indicators are important for evaluating the severity of patients with ischemic cerebrovascular disease.