Dongwen Zheng*, Jie Jiang, Guoyu Xu, Huijuan Li, Hongmei Zhou
Department of Nephrology, Dongguan People's Hospital, Dongguan 523000, China
Objective: To explore the correlation between serum stem cell factor (SCF) level and disease activity, pathological type, and refractory degree of lupus nephritis.
Methods: Eighty-five patients with lupus nephritis were randomly selected from patients treated in the Ya’an Polytechnic College Affiliated Hospital from May 2018 to January 2020. They were divided into a disease activity group (43 cases) and a stable disease group (42 cases) based on whether their systemic lupus erythematosus disease activity scores (SLEDAI) were over 10 points. According to the new standard for pathological classification of lupus nephritis, they were classified as type I (0 cases), type II (10 cases), type III (14 cases), type IV (18 cases), type V (21 cases), type VI (0 cases), and mixed type (type Ⅲ + Ⅴ, 12 cases; type Ⅳ + Ⅴ, 10 cases). The patients were divided into a refractory lupus group (29 cases) and a treatment-sensitive group (56 cases) based on their response to therapy. A total of 43 normal healthy subjects who underwent physical examination in our hospital during the same period were selected as the control group. Changes in erythrocyte sedimentation rate (ESR), complement C3 level, complement C4 level, serum SCF level, clinical index, activity index (AI), and pathological index were measured. The Pearson correlation test was used to analyze the correlations between the serum SCF level and ESR, complement C3, complement C4, UTP, antinuclear antibody (ANA) titer, anti-dsDNA quantification, SLEDAI score, AI, CI, and renal tubulointerstitial disease (TIL) score.
Results: Serum SCF and ESR levels of patients in the disease activity group and the stable disease group were significantly higher than those of patients in the control group, and levels in the disease activity group were significantly higher than those in the stable disease group (P<0.05). The levels of complement C3 and complement C4 were markedly lower in the disease activity group and stable disease group than in the control group, and those in the disease activity group were clearly lower than those in the stable disease group (P<0.05). The serum SCF levels of type III and IV patients were significantly higher than those of type II and V patients (P<0.05). Compared with those in the treatment-sensitive group, serum SCF levels in the refractory lupus group were significantly greater (P<0.05). UTP, SLEDAI score, ANA titer, anti-dsDNA level, AI index, TIL score, and CI index were significantly greater in the disease activity group (P<0.05) than in the stable disease group. Pearson correlation analysis showed that SCF was positively correlated with ESR, ANA titer, anti-dsDNA quantification, SLEDAI score, AI index, and TIL score, and negatively correlated with complement C3 and complement C4 (P<0.05). There was no significant correlation between SCF level and CI index (P>0.05).
Conclusion: The serum SCF level of lupus nephritis patients was obviously higher than that of the normal control group, and SCF level was significantly correlated with the disease activity, pathological type, and refractory degree of lupus nephritis, indicating that it can play an important role in determining the prognosis of patients.
SCF, lupus nephritis, disease activity, pathological type, refractory degree, correlation.