CORRELATION BETWEEN SERUM EHSP70 LEVEL AND SERUM ANG-2, ISS SCORE AND APACHE Ⅱ IN TRAUMA PATIENTS

Haibin Weng^* 

Department of Emergency, Liaocheng People’s Hospital, Liaocheng 252000, Shandong, China

Objective: To study the correlation between serum extracellular heat shock protein 70 (eHSP70) level and serum angiopoietin 2 (Ang 2), acute physiology and chronic health evaluation II (APACHE II), and injury severity score (ISS) in trauma patients. 

Methods: Forty-eight trauma patients who were treated in our hospital from June 2018 to December 2019 were collected and divided according to ISS score into a mild trauma group (ISS score ≤ 16 points, 18 cases), a moderate trauma group (16 points <ISS score <25 points, 16 cases), and a severe trauma group (ISS score ≥ 25 points, 14 cases). Another 22 adults under physical examination in our hospital were selected as the normal control group. The peripheral blood of each group was drawn for testing, and the serum eHSP70 and Ang 2 levels, APACHE II, and ISS score were compared.  According to the prognosis of trauma patients, they were divided into survival group and death group, and the serum eHSP70 and Ang 2 levels of the subjects in each group were compared. The correlation between the serum eHSP70 level, Ang 2 level, ISS score, and APACHE Ⅱ of trauma patients was further analyzed. 

Results: The APACHE II and ISS score of patients in the mild trauma group, moderate trauma group, and severe trauma group were significantly higher than those in the normal control group (P<0.05). Moreover, the APACHE II and ISS scores in the mild and moderate trauma groups were significantly lower than those in the severe trauma group (P<0.05). No significant difference was revealed in APACHE II between the mild trauma group and the moderate trauma group (P>0.05). The ISS score in the moderate trauma group was significantly higher than that in the mild trauma group (P<0.05). The levels of eHSP70 and Ang 2 in the mild trauma group, moderate trauma group, and severe trauma group were significantly higher than those in the normal control group (P<0.05). The levels of eHSP70 and Ang 2 in the mild and moderate trauma groups were significantly lower than those in the severe trauma group (P<0.05). No significant difference was seen in the levels of eHSP70 and Ang 2 between the mild trauma group and the moderate trauma group (P>0.05). The eHSP70 and Ang 2 levels in the survival group were significantly higher than those in the normal control group (P<0.05). The eHSP70 and Ang 2 levels in the death group were significantly higher than those in the survival group (P<0.05). eHSP70 was taken as the dependent variable, and Ang 2, ISS score, and APACHE Ⅱ were taken as independent variables to analyze the correlation. Results showed that eHSP70 was positively correlated to Ang 2, ISS score, and APACHE Ⅱ (P<0.05). 

Conclusion: The serum eHSP70 and Ang 2 levels, ISS score, and APACHE Ⅱ of trauma patients are significantly increased, and the serum eHSP70 level is positively correlated to Ang 2 level, ISS score, and the APACHE Ⅱ of trauma patients.