ADVANCES IN THE STUDY OF ACTIVATED PLATELETS IN SYSTEMIC LUPUS ERYTHEMATOSUS

Ling Ren¹, Jing Liu², Man Luo³, Guohua Yuan^{2, *} 

¹North Sichuan Medical College, Nanchong City, Sichuan Province -²North Sichuan Medical College: Institute of Rheumatology and Immunology, Nanchong City, Sichuan Province -³Suining Central Hospital, Suining City, Sichuan Province

Platelets are involved not only in coagulation and thrombosis but also in the inflammatory response. Systemic lupus erythematosus (SLE) is an autoimmune-mediated chronic inflammatory disease. Studies have shown that hyperactivated platelets promote the occurrence and development of inflammation by interacting with other cells and thus participating in the pathogenesis of SLE. Therefore, this article reviews the platelet activation pathway, the interaction between activated platelets and immune cells, and their role in SLE to investigate the mechanism of activated platelets in SLE inflammation.