A COMPARATIVE STUDY OF BUTYLPHTHALIDE AND URINARY KALLINDINOGENASEON REVASCULARIZATION RATE AND VASCULAR REOCCLUSION AFTER MECHANICAL THROMBECTOMY FOR CEREBRAL INFARCTION

Rongyan Mao^{1, *}, Xin Wang¹, Zhigang Zhu²

¹Department of Neurology, Yiwu Central Hospital, Yiwu, 322000, China - ²Department of Neurosurgery, Yiwu Central Hospital, Yiwu, 322000, China

Objective: To study the effects of butylphthalide and urinary kallindinogenaseon the revascularization rate and revascularization after mechanical thrombectomy for cerebral infarction. 

Methods: Patients with acute ischemic stroke admitted to our hospital from February 2015 to January 2020 who underwent mechanical thrombectomy were retrospectively selected and divided into the urinary kallindinogenasegroup, the butylphthalide group and the combined treatment group. Patients were evaluated with NIHSS score. The cerebral infarction area was measured by MRI. The incidence of vascular re-occlusion was calculated, and serum levels of VEGF and HIF-1α were measured. 

Results: After 14 days of drug treatment, there was no significant difference in NIHSS score between the urinary kallindinogenasegroup and the butylphthalide group (P>0.05). While the NIHSS score of the combined treatment group was significantly lower than that of the urinary kallindinogenase group (P<0.01) and the butylphthalide group (P<0.05),the effective rate of the combined treatment group was significantly higher than that of the urinary kallindinogenasegroup (P<0.05) and the butylphthalide group (P<0.05); there was no significant difference in cerebral infarction volume between the urinary kallindinogenasegroup and the butylphthalide group (P>0.05), and the cerebral infarction volume in the combined treatment group was significantly lower than that in the urinary kallindinogenasegroup (P<0.01) and the butylphthalide group (P<0.05); there was no significant difference in the incidence of vascular reocclusionamong the three groups (P>0.05). After 14 days of drug treatment, the serum VEGF level in the combined treatment group was significantly higher than that in the urinary kallindinogenase and the butylphthalide groups (P<0.05), while there was no significant difference in serum VEGF level between the urinary kallindinogenase group and the butylphthalide groups (P>0.05);the serum HIF-1 level of the patients in the combined treatment group was significantly lower than that of the urinary kallindinogenase group and the butylphthalide group (P<0.05), and the serum HIF-1α level of the butylphthalide group was significantly lower than that of the urinary kallindinogenase group (P<0.05). 

Conclusion: The combination of urinary kallindinogenaseand butylphthalide was more effective in improving the associated symptoms, reducing the volume of cerebellar infarction, and promoting the formation of new blood vessels in patients with acute ischemic stroke than any single drug.