Gulden Eser Karlidag
University of Health Sciences, Fethi Sekin City Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Elazig, Turkey
Introduction: Because uremia and aging are associated with the impairment of lymphocyte and granulocyte function, the reduced immune response in elderly patients undergoing hemodialysis with chronic renal failure may adversely affect the response to SARS-CoV-2 infection. This study aimed to evaluate the relationship between survival and age and other prognostic factors in patients with COVID-19 undergoing hemodialysis.
Materials and methods: The demographic, clinical, laboratory, and radiological data of patients with chronic renal failure who underwent hemodialysis treatment and had a positive polymerase chain reaction test for SARS-CoV-2 were retrospectively reviewed. The study group was divided into two groups: patients aged 59 and below and those aged 60 and above.
Results: Analyses of all patients in our study revealed that the mortality rate was 16.6%, while it was 23.7% in the group aged 60 years and above. The most common symptoms observed in patients aged 60 years and above were muscle-joint pain, respiratory distress, and cough. Evaluation of surviving and deceased patients demonstrated that the advanced age, male sex, and presence of respiratory distress were significantly associated with death. A decrease in lymphocyte, thrombocyte, and albumin levels and an increase in neutrophil, urea, C-reactive protein, procalcitonin, D-dimer, and troponin levels were reported in patients who died; this difference was statistically significant.
Conclusion: Thus, these data show that previous kidney disease may be a risk factor for a more severe course of COVID-19, particularly in elderly patients. Implementation of infection control measures and prevention of disease transmission should be the primary goal.
COVID-19, Hemodialysis, Age, Chronic renal failure, Elderly, Survival.