THE RELATIONSHIP BETWEEN SERUM LEVELS OF FGF-21, ANGPTL 2 AND NESFATIN-1 AND INSULIN RESISTANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Shuangjie Zhang¹, Lili Xu², Xueming Li³, Chenhong Zhou^{4, *}

¹Department of Internal Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, PR China - ²Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, PR China - ³School of Pharmaceutical Science, Nanjing Tech University, Nanjing, PR China - ⁴Department of Endocrinology, The West District of Qingdao Municipal Hospital, Qingdao, PR China

Objective: To analyse the relationship between the levels of serum fibroblast growth factor 21 (FGF-21), angiopoietin like protein 2 (ANGPTL 2), feeding inhibition factor (nesfatin-1) and insulin resistance (IR) in patients with type 2 diabetes. 

Methods: Fifty-six patients with type 2 diabetes treated in the Endocrine Department of our hospital from April 2016 to September 2017 were selected as the observation group, and 56 healthy subjects in the same period were selected as the control group. Fasting blood glucose (FBG) and glycosylated haemoglobin (HbAlc) were measured by the glucose oxidase method. The levels of serum insulin resistance index (IR), fasting insulin (FINS) and blood lipid indexes (total cholesterol [TC], triglyceride [TG], low density lipoprotein [LDL] and high density lipoprotein [HDL]) were measured by enzyme-linked immunosorbent assay (ELISA). The levels of FGF-21, ANGPTL 2, nesfatin-1, FBG, HbAlc, TC, TG, IDL, HDL and IR were analysed. 

Results: Compared with the control group, the levels of FBG, HbAlc, IR and FINS in the observation group were significantly higher, and the differences were statistically significant (P<0.05). The levels of TC, TG and LDL in the observation group were significantly higher than those in the control group, and the level of HDL was significantly lower than that in the control group (P<0.05). Compared with the control group, the levels of FGF-21, Angptl 2 and nesfatin-1 in the observation group were significantly higher, and the differences were statistically significant (P<0.05). Pearson correlation analysis revealed that IR was positively correlated with FBG, HbAlc, FGF-21, Angptl2, nesfatin-1, TC, TG and LDL (P<0.05), and negatively correlated with FINS and HDL (P<0.05). 

Conclusion: The serum levels of FGF-21, nesfatin-1, FBG, HbAlc, TC, TG and IDL in patients with type 2 diabetes mellitus are significantly higher than those in healthy subjects, and the levels of Angptl 2 and HDL are significantly lower than those in healthy subjects; in addition, the above indexes have a certain correlation with IR.