Semih Kalyon


Prof. Dr. Cemil Taşcioğlu City Hospital Istanbul, Internal Medicine, Turkey


Introduction: Insulin resistance plays an important role in the etiology of non-alcoholic fatty liver disease. The purpose of this study is to examine the relationship between blood calcium, magnesium, and vitamin D levels, and the presence and degree of liver steatosis, which was shown to be associated with insulin resistance in some previous studies. 

Material and methods: In this study conducted in a single-center after the approval of the ethics committee; the blood calcium, magnesium, and vitamin D levels of the patients with liver steatosis were retrospectively analyzed from the records. Those under 18 years of age, pregnant women, patients with malignancy, chronic kidney or liver disease, and diabetes were not included in the study. The data were evaluated with the NCSS program and Shapiro-Wilk, Student-t, Mann-Whitney U, Kruskal-Wallis, Dunn-Bonferroni, Pearson chi-square tests were used. 

Results: In this study conducted with a total of 346 cases, 242 women and 104 men, the mean age of the participants was 56 years. When we divided the cases into two groups as with and without liver steatosis, the ages, genders, calcium, magnesium, and vitamin D levels of both groups were similar. When the patients with hepatosteatosis were sub-grouped regarding the degree of steatosis, these results were also similar between the subgroups (p> 0.05).

Conclusion: There is no relationship between the blood level of calcium, magnesium, and vitamin D and the presence and stage of fatty liver disease.


Vitamin D, Calcium, Magnesium, Hepatosteatosis.