Authors

Fuli Zhu1, *, Junyue Huang2


Departments

1Department of Cardiology, Beijing LuHe Hospital, Capital Medical University, Beijing, PR China - 2Department of Nephrology, Gansu People’s Hospital, Lanzhou, PR China

Abstract

Objective: To examine the expression levels of hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), angiopoietin I (AngI)in peripheral arterial blood and coronary artery blood of patients with acute coronary syndromes (ACS) and the relationship with disease severity.

Methods: We analysed 148 ACS patients treated by coronary angiography (CAG) in our hospital from July 2016 to June 2017. In addition, there were 50 volunteers with normal CAG results in a control group. The expression levels of HGF, PDGF, VEGF and AngI in the peripheral arterial blood of all volunteers and coronary artery blood of ACS patients were detected and compared.

Results: The expression levels of HGF and PDGF in coronary artery blood of ACS patients were higher than the levels in peripheral arterial blood (p<.05); but the expression levels of VEGF and AngI in coronary artery blood of ACS patients were lower than the levels in peripheral arterial blood (p<.05). The expression levels of HGF, PDGF and VEGF in the peripheral arterial blood of ACS patients were higher than in the control group (p<.05). However, there was no statistical significance of AngI between the two groups (p>.05). The Gensini score of ACS patients was (36.93±1.47), which was higher than the control group (p<.05). The Gensini score had a positive correlation with HGF, PDGF and VEGF (p<.05); but there was no relationship between the Gensini score and AngI (p>.05).

Conclusion: There were significant differences in the levels of HGF, PDGF, VEGF and AngI in peripheral arterial blood compared to coronary artery blood of patients with acute coronary syndromes. (HGF and PDGF were higher; VEGF and AngI were lower.) In addition, the levels of HGF, PDGF and VEGF in the peripheral arterial blood of patients with acute coronary syndromes could be higher than in the control group and they were correlated with disease severity.

Keywords

Acute coronary syndromes, coronary artery blood, Gensini score, hepatocyte growth factor, platelet-derived growth factor.

DOI:

10.19193/0393-6384_2021_2_149