The effects of chrysin on burn healing

Muhammet Gokhan Turtay¹, Osman Ciftci², Asli Cetin³, Sukru Gurbuz¹, Hakan Oguzturk¹, Nese Basak⁴, Cemal Firat⁵, Taner Guven⁶, Kasım Turgut⁷

¹Department of Emergency Medicine, Faculty of Medicine, Inonu University, Malatya, Turkey - ²Department of Medical Pharmacology, Faculty of Medicine, Inonu University, Malatya, Turkey - ³Department of Histology and Embryology, Faculty of Medicine, Inonu University, Malatya, Turkey - ⁴Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Inonu University, Malatya, Turkey - ⁵Department of Plastic Surgery, Faculty of Medicine, Inonu University, Malatya, Turkey - ⁶Department of Emergency Medicine, State Hospital of Malatya, Malatya, Turkey - ⁷Department of Emergency Medicine, State Hospital of Adiyaman, Adiyaman, Turkey

Introduction: This study aims to investigate the effects of chrysin on burn healing in burned model rats. 

Materials and methods: Rats were burned and randomly divided into four groups. Group 1; the group whose burn wound was left to secondary healing. Group 2; the group to which bacitracin neomycin sulfate pomade was topically administered. Group 3; the group to which chrysin was administered topically and with gastric gavage. Group 4; the group was assigned as the group to which chrysin and bacitracin neomycin sulfate was administered. 

Results: On days 3, 7 and 14, blood samples and skin biopsies were taken. Necrosis, congestion, hemorrhage and IL-1β were found to have the lowest levels on all days when bacitracin and chrysin were administered together. This group was also found to have the lowest level of TNF-α serum levels on days 7 and 14. 

Conclusion: We conclude that chrysin is effective in the treatment of burn wounds when used separately, but when combined with topical bacitracin pomade application, it is more effective for healing.