Muhammet Gokhan Turtay1, Osman Ciftci2, Asli Cetin3, Sukru Gurbuz1, Hakan Oguzturk1, Nese Basak4, Cemal Firat5, Taner Guven6, Kasım Turgut7
1Department of Emergency Medicine, Faculty of Medicine, Inonu University, Malatya, Turkey - 2Department of Medical Pharmacology, Faculty of Medicine, Inonu University, Malatya, Turkey - 3Department of Histology and Embryology, Faculty of Medicine, Inonu University, Malatya, Turkey - 4Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Inonu University, Malatya, Turkey - 5Department of Plastic Surgery, Faculty of Medicine, Inonu University, Malatya, Turkey - 6Department of Emergency Medicine, State Hospital of Malatya, Malatya, Turkey - 7Department of Emergency Medicine, State Hospital of Adiyaman, Adiyaman, Turkey
Introduction: This study aims to investigate the effects of chrysin on burn healing in burned model rats.
Materials and methods: Rats were burned and randomly divided into four groups. Group 1; the group whose burn wound was left to secondary healing. Group 2; the group to which bacitracin neomycin sulfate pomade was topically administered. Group 3; the group to which chrysin was administered topically and with gastric gavage. Group 4; the group was assigned as the group to which chrysin and bacitracin neomycin sulfate was administered.
Results: On days 3, 7 and 14, blood samples and skin biopsies were taken. Necrosis, congestion, hemorrhage and IL-1β were found to have the lowest levels on all days when bacitracin and chrysin were administered together. This group was also found to have the lowest level of TNF-α serum levels on days 7 and 14.
Conclusion: We conclude that chrysin is effective in the treatment of burn wounds when used separately, but when combined with topical bacitracin pomade application, it is more effective for healing.
Chrysin, Bacitracin, Burn, Rat.