Authors

Bin Li1, Yanjie Qi1, Fan He1, Yun Chen1, Xiaoyu Han2, Yi Zheng1, * 


Departments

1Department of Pediatrics, Beijing Anding Hospital, Capital Medical University; The National Clinical Research Center for Mental Disorders; Beijing Key Laboratory of Mental Disorders; Beijing Institute for Brain Disorders, Beijing, PR China - 2Clinical Examination Center, Beijing Traditional Chinese Medical Hospital, Beijing, PR China

Abstract

Objective: To explore the relationship between BDNF, MBP, S100β and PANSS in children with schizophrenia. 

Methods: For this study, 60 schizophrenic patients admitted to our hospital from February 2014 to April 2019 were selected as the observation group, and 60 healthy volunteers were recruited as the control group. The patients in the observation group were treated with risperidone. The levels of BDNF, MBP and S100β in serum were measured by double-antibody sandwich enzyme-linked immunosorbent assay. According to PANSS score, the mental symptoms of children before and after treatment were analysed. The correlation between serum BDNF, MBP, S100β and PANSS score was analysed by sparson correlation test. The changes of BDNF, MBP, S100β and PANSS were analysed after treatment. 

Results: Compared with the control group, the BDNF level before treatment in the observation group was significantly lower (P<0.01), and the PANSS level was significantly higher (P<0.01). After treatment, the BDNF level in the observation group was significantly higher (P<0.01), and the PANSS level was significantly lower (P < 0.01). Compared with the control group, the MBP level before treatment in the observation group was significantly lower (P<0.01), while the S100β level was significantly higher (P<0.01). After treatment, the MBP level of the observation group was significantly higher (P < 0.01), S100β level was significantly lower (P<0.01). The noted differences were statistically significant (P<0.01). A negative correlation was seen between the serum BDNF, MBP level and PANSS score in contrast to a positive correlation between S100β level and PANSS score, a statistically significant difference (P<0.05). 

Conclusion: The serum BDNF and S100β in schizophrenic children were significantly lower than those in normal people. Furthermore, the serum BDNF, MBP and S100 β levels were significantly correlated with PANSS scores.

Keywords

Child schizophrenia, serum brain-derived neurotrophic factor, myelin basic protein, calcium-binding protein, PANSS.

DOI:

10.19193/0393-6384_2021_2_166