Correlation between serum neuron specific enolase level and neuron injury index and neuron apoptosis index in patients with brain injury

Xiaoping Wang

Department of Neurosurgery, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, PR China

Objective: To analyze the correlation between the level of NSE and the indexes of neuron injury and apoptosis. 

Methods: From May 2017 to June 2019, 66 patients with craniocerebral injury in the neurosurgery of our hospital were selected as the observation group and 66 healthy people as the control group. NSE level, neuron injury index [S100B, fatty acid binding protein (FABP), and insulin-like growth factor-1 (IGF-1)], and neuron apoptosis index [B lymphoma-2 (Bcl-2) and soluble wilt] were compared, as were the correlation of apoptosis-related factor ligand (sFasL) and soluble apoptosis-related factor (sFas). 

Results: The NSE level of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P < 0.01). The IGF-1 level of the observation group was significantly lower than that of the control group, and the FABP and S100B levels were significantly higher (P < 0.01). The sFasL and sFas levels of the observation group were significantly higher than those of the control group, and the Bcl-2 level was significantly lower (P < 0.01). NSE was positively correlated with S100B, FABP, sFasL, and sFas, and negatively correlated with IGF-1 and Bcl-2 (P < 0.05).

Conclusion: Serum NSE level in patients with craniocerebral injury can reflect the degree of neuron injury and apoptosis, which can predict the severity of the injury and has certain clinical value for patients.