Authors

Kewei Yu1, Hongyu Qian1, Zhiheng Xing2, Haiying Peng1, Bin Liu1


Departments

1Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin, 300000, China - 2Medical Imaging Department, Tianjin Haihe Hospital, Tianjin, 300000, China

Abstract

Objective: To explore the baseline characteristics and gene mutation spectrum of non-small-cell lung cancer (NSCLC) patients with tuberculosis and provide more references for clinical diagnosis and treatment. 

Methods: The clinical data of 102 NSCLC patients with tuberculosis admitted to our hospital from January 2015 to June 2020 were analyzed retrospectively. The baseline characteristics and gene mutation spectrum were analyzed to evaluate the correlation between the two. 

Results: Among 102 patients, the proportion of males with smoking history was significantly higher than that of females (P<0.05). 54 patients received genetic testing, accounting for 52.94%. There was no significant difference between the whole population and those received genetic testing in terms of baseline characteristics (P<0.05). The percentage of active tuberculosis in patients with Stage IIIB-IV was significantly higher than that in patients with Stage I-IIIA (P<0.05). There was significant dif-ference between patients with and without cavity changes in the chest in histopathological type (P<0.05). The mutation rates of epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) fusion, KRAS proto-oncogene (KRAS), ROS proto-oncogene 1,receptor tyro sine kinase (ROS1) and sarcoma viral oncogene homolog B1 (BRAF) were 35.90%, 4.00%, 10.00%, 3.70% and 4.55%, re-spectively; In NSCLC patients with tuberculosis, the gene mutation rate in females was significantly higher than that in males (P<0.05). The gene mutation rate of those without smoking history was significantly higher than those with smoking history (P<0.05). The gene mutation rate of those with adenocarcinoma was significantly higher than those without adenocarcinoma (P<0.05). The gene mutation rate of those with squamous carcinoma was significantly lower than those without squamous carcinoma (P<0.05). The gene mutation rate of those without cavity changes in the chest was signif-icantly higher than those with cavity changes in the chest (P<0.05). The mutation rate of EGFR of those without cavity changes in the chest was significantly higher than those with cavity changes in the chest (P<0.05). 

Conclusion: NSCLC with tuberculosis has a high incidence in men who smoke for a long time, with adenocarcinoma as its main pathological type. At the same time, the gene mutation rates of NSCLC patients with tuberculosis are equivalent to those of NSCLC patients without tuberculosis. Patients with cavity changes in the chest have lower gene mutation rate.

Keywords

Tuberculosis, non-small-cell lung cancer, histopathology, gene mutation.

DOI:

10.19193/0393-6384_2021_2_193