Shumin Wang, Mei Ping, Gehong Zhang, Yarong Guo, Yuanfei Li, Junmei Jia*
Department of Oncology, the First Hospital of Shanxi Medical University, Taiyuan 030001, PR China
Objective: To investigate the prognosis survival rate of patients with stage Ⅱ - Ⅲ gastric cancer treated by sequential radiotherapy and chemotherapy, and the clinical observation of the side effects of radiotherapy and chemotherapy.
Methods: A total of 126 patients with stage Ⅱ - Ⅲ gastric cancer from April 2014 to August 2016 were randomly selected and randomly divided into a study group and control group according to the random number table method, with 63 patients in each group. The patients in the study group were treated with sequential radiotherapy (chemotherapy radiotherapy chemotherapy), whereas the patients in the control group were treated with simple chemotherapy. The clinical data, recurrence rate, distant metastasis rate, prognosis survival rate and the occurrence of side effects were compared between the study group and the control group.
Results: there was no significant difference in age, gender, TNM stage and differentiation between the study group and the control group (P>0.05). Compared with the control group, the recurrence rate of patients in the study group was significantly lower, the overall prognostic survival rate was significantly higher (P < 0.05) and the distant metastasis rate had no significant difference (P>0.05). There was no significant difference between the two groups (P > 0.05). The overall prognosis survival rate was significantly higher in the study group than in the control group. Compared with the control group, the patients in the study group had decreased nausea, vomiting, oral mucositis, appetite decline, leucopoenia, thrombocytopenia, etc., but there was no significant difference between the two groups (P>0.05). The incidence of liver and kidney dysfunction and diarrhoea in the study group was significantly lower than that in the control group (P<0.05).
Conclusion: The prognosis survival rate of patients with stage Ⅱ-Ⅲ gastric cancer undergoing sequential chemoradiotherapy is significantly higher than that of chemotherapy alone. However, in terms of the toxic and side effects of radiochemotherapy, sequential radiochemotherapy is safer.
Stage Ⅱ-Ⅲ, gastric cancer, sequential chemoradiotherapy, prognostic survival rate, toxic and side effects.