Are Basic Inflammation Markers Sufficient for Predicting Covid 19 Infection

Neslihan Ergün Süzer¹, Emel Erkus Sirkeci², Ozgur Sirkeci³ Turgay Ulas⁴

¹Gebze Fatih Governmet Hospital Emergency Department  Gebze,Kocaeli - ²Near East University Hospital Emergency Department, Nicosia, Cyprus - ³Near East University Hospital Internal Medicine Department, Nicosia, Cyprus - ⁴Near East University Hospital Hematology Department, Nicosia, Cyprus

Introduction: Although Covid 19 is a systemic disease lung involvement causes the main clinical outcomes. As chest ct, inflammatory markers were other important parameters that provide information about the disease course. 

Methods: We enrolled 150 in-hospital patients between 02 April 2020-03 May 2020. The severity of disease classified as mild, moderate, severe, and critically ill. Chest CT of the patients assessed and classified for the degree of parenchyma involvement and noted as following: No involvement (0%), Minimal involvement (1-25%) Mild involvement (26-50%), Moderate involvement (51-75%) and severe involvement 76-100%) The relationship between inflammatory markers, chest ct and severity of disease statistically evaluated. 

Results: There were no statistical differences between the Chest CT involvement and INR, Ast, Alt, Creatinine, Uric acid, Platelet, White blood cell and procalcitonin levels (all p > 0.05). A positive correlation was found between Ct involvement and fibrinogen, D-dimer, sedimentation rate, ferritin, NLR, Crp (r = 0.478, p = <0.001; r =0.311, p = <0.001; r =0.455, p = <0.001; r= 0.369, p = <0.001; r= 0.584, p = <0.001, respectively) Roc analysis revealed that CRP>9.5 mg/L predicted the severe disease with 96% sensitivity and 97.5% specificity.

Conclusion: Evaluating Covid 19 infection with easily accessible markers is important. Crp, D-dimer, Ferritin and NLR stands out to as easily accessible, cheap, and reliable markers in determining the prognosis of disease.