APPLICATION OF TIOTROPIUM BROMIDE, PULMICORT RESPULES AND VANTOLIN IN PATIENTS WITH COPD AND EMPHYSEMA AND ITS EFFECT ON LUNG FUNCTION

Feng Lu¹, Shicong Wang², Lidian Chen^{1, *} 

¹Fujian University of Traditional Chinese Medicine, Fuzhou, PR China - ²The Second Affiliated Hospital of Fujian University of traditional Chinese Medicine, Fuzhou, PR China

Objective: To analyse the application of tiotropium bromide, Pulmicort Respules and Ventolin in patients with chronic obstructive pulmonary disease (COPD) complicated with emphysema, along with its effect on lung function.

Methods: A total of 98 patients with COPD and emphysema treated in our hospital from January 2015 to January 2018 were enrolled in the study. They were randomly assigned into an observation group and a control group, 49 patients per group. The control group was treated with Pulmicort Respules and Ventolin, and the observation group was treated with tiotropium bromide, Pulmicort Respules and Ventolin. After treatment, the difference in clinical efficacy, time to disappearance of clinical symptoms (such as wheezing, coughing, fever, dry and wet rales), length of hospital stay, lung function (FEV1, FVC, FEV1 / FVC) and blood gas analysis (PaO2, PaCO2, SaO2, pH) were compared between the two groups. 

Results: After treatment, the total effective rate was 93.87% in the observation group, much higher than the control group's 81.63, a statistically significant difference (P<0.05). Symptoms for the patients in the observation group, such as wheezing, coughing, fever, and dry and wet rales, disappeared in a shorter time; patients in this group also exhibited a shorter length of hospital stay than those in the control group. The difference between the two groups was statistically significant (P<0.05). Before treatment, no significant difference was noted in FEV1, FVC and FEV1/FVC between the two groups (P>0.05). After treatment, FEV1, FVC and FEV1/FVC in both groups were significantly higher than before treatment, and those in the observation group showed statistically significant higher levels than the control group (P<0.05). Before treatment, no statistical difference in PaO2, PaCO2, SaO2 and pH could be seen between the two groups (P>0.05). After treatment, PaCO2 in both groups was significantly lower than before treatment, and that in the observation group was significantly lower than for those in the control group (P<0.05). Moreover, the levels of PaO2, SaO2 and pH were significantly higher than before treatment, and those in the observation group showed significantly higher levels than the control group, a statistically significant difference (P<0.05). 

Conclusions: Tiotropium bromide, Pulmicort Respules and Ventolin can improve the lung function and blood gas indicators of COPD patients with emphysema.