ANALYSIS OF RISK FACTORS FOR BENIGN PAROXYSMAL POSITIONAL VERTIGO IN PATIENTS WITH SPONTANEOUS INTRACRANIAL HYPOTENSION

Lili Chen^{1, #}, Guangyu Ying^{2, #}, Wen Lv^{3, *}

¹Department of Neurology, Xiasha Campus, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou, 310000, China - ²Department of Neurosurgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China - ³Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China

Background: Few studies analyzed the association of spontaneous intracranial hypotension (SIH) and benign paroxysmal positional vertigo (BPPV), so the risk factors for BPPV in SIH patients remain unclear. 

Materials/methods: In 2014-2017, we enrolled 29 SIH patients from our hospital who had symptoms of BPPV. Control subjects were selected from the people with no symptoms of BPPV in one year, for a total of 76 SIH patients. We collected clinical data, including age, gender, disease history, symptoms, blood pressure, imaging findings and laboratory examination results. 

Results: The mean ages of BPPV and non-BPPV cohorts were 45.379 (standard deviation (SD)=11.700) and 40.803 (SD=10.466) years old, respectively. We found that smoking status (P=0.041), time in bed after admission (P=0.003), and a positive venous distension sign (VDS) (P=0.013) were associated with the presence of BPPV. A multiple logistic regression model showed that time in bed after admission (P=0.014) and a positive venous distension sign (P=0.041) were strongly correlated with the presence of BPPV.

Conclusions: Our study indicated that long-term bed rest and a positive venous distension sign are potential risk factors for the occurrence of idiopathic BPPV in SIH inpatients. Other potential factors need further investigation.