Lili Chen1, #, Guangyu Ying2, #, Wen Lv3, *
1Department of Neurology, Xiasha Campus, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou, 310000, China - 2Department of Neurosurgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China - 3Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China
Background: Few studies analyzed the association of spontaneous intracranial hypotension (SIH) and benign paroxysmal positional vertigo (BPPV), so the risk factors for BPPV in SIH patients remain unclear.
Materials/methods: In 2014-2017, we enrolled 29 SIH patients from our hospital who had symptoms of BPPV. Control subjects were selected from the people with no symptoms of BPPV in one year, for a total of 76 SIH patients. We collected clinical data, including age, gender, disease history, symptoms, blood pressure, imaging findings and laboratory examination results.
Results: The mean ages of BPPV and non-BPPV cohorts were 45.379 (standard deviation (SD)=11.700) and 40.803 (SD=10.466) years old, respectively. We found that smoking status (P=0.041), time in bed after admission (P=0.003), and a positive venous distension sign (VDS) (P=0.013) were associated with the presence of BPPV. A multiple logistic regression model showed that time in bed after admission (P=0.014) and a positive venous distension sign (P=0.041) were strongly correlated with the presence of BPPV.
Conclusions: Our study indicated that long-term bed rest and a positive venous distension sign are potential risk factors for the occurrence of idiopathic BPPV in SIH inpatients. Other potential factors need further investigation.
Spontaneous intracranial hypotension, benign paroxysmal positional vertigo, positive venous distension sign.