Zhengrong Peng1, *, Su’e Wang2, Fangling Huang1, Xu Huang1
1Department of Hyperbaric Oxygen, Xiangya Hospital of Central South University, Changsha, PR China - 2Department of Prevention and Health Care, Xiangya Hospital of Central South University, Changsha, PR China
Objective: To analyse the related factors affecting prognosis in the case of hyperbaric oxygen treatment for acute carbon monoxide (CO) poisoning.
Methods: Selected study subjects comprised 116 patients with acute CO poisoning admitted to our hospital from February 2016 to February 2019. General data for all patients were collected, such as sex, age, clinical symptoms, cause of poisoning, whether hyperbaric oxygen therapy was carried out, time interval from poisoning to hyperbaric oxygen therapy and the number of repetitions of hyperbaric oxygen therapy. Single factor analysis was performed to analyse the relationship between the above data and the prognostic effect. A logistic regression model was used to analyse the risk factors affecting the prognosis of patients with acute CO poisoning who received hyperbaric oxygen therapy.
Results: Among the 116 patients, 67 patients had acute CO poisoning caused by the use of coal stoves for heating, accounting for 57.76%, followed by poisoning from a gas water heater at 16.38%. Of the 116 patients, 108 patients received hyperbaric oxygen therapy, resulting in a recovery rate of 72.22% (78/108), an effective rate of 91.67% (21/108) and an incidence of delayed encephalopathy of 8.33% (9/108). Single factor analysis showed that the age distribution, the time interval from poisoning to hyperbaric oxygen treatment, the degree of poisoning and the repetitions of hyperbaric oxygen treatment related to a statistically significant difference in prognosis (P<0.05). Logistic regression analysis showed that patient age greater than 60 years, a time interval from poisoning to hyperbaric oxygen treatment of more than 12 hours, a severe degree of poisoning, and more than 30 iterations of hyperbaric oxygen treatment were all risk factors in the prognosis of patients with acute CO poisoning (P<0.05).
Conclusion: The primary cause of acute CO poisoning is coal stove heating. Patient age above 60 years old, time interval from poisoning to hyperbaric oxygen treatment more than 12 hours, severe degree of poisoning and more than hyperbaric oxygen treatments are all risk factors affecting the prognosis of hyperbaric oxygen treatment in patients with acute CO poisoning.
Acute carbon monoxide poisoning, hyperbaric oxygen treatment, prognosis effect, related factor.