THE EFFECT OF HYPERBARIC OXYGEN THERAPY ON SERUM HMGB-1, GSN, IGF-1, VASCULAR ENDOTHELIAL FUNCTION AND IMMUNE FUNCTION IN PATIENTS WITH HYPERTENSIVE CEREBRAL HEMORRHAGE

Yonghong Yang^*, Yujie Zhang, Yanxin Zhu, Fengqiong Xia

Department of Medical Laboratory, Guizhou Province Orthopaedic Hopspital, Guiyang, PR China

Objective: To analyse the effect of hyperbaric oxygen on serum HMGB-1, GSN, IGF-1, vascular endothelial function, and immune function in patients with hypertensive cerebral haemorrhage. 

Methods: 240 patients with hypertensive intracerebral haemorrhage admitted to our hospital between June 2015 and April 2018 were divided into a study group (120 cases) and a control group (120 cases) according to the random number table method. The control group was given basic treatment, such as oxygen inhalation, intracranial pressure reduction, water electrolyte balance maintenance, anti-infection and vital sign detection. The study group was given hyperbaric oxygen treatment on the basis of the control group. For patients who had hypertensive intracerebral haemorrhage after treatment, the high mobility group protein B1 (HMGB-1), gelsolin (GSN), insulin-like growth factor (IGF) -1, vascular endothelial function [nitrogen oxide (NO), endothelin (ET-1)], immune function [T lymphocyte subsets (CD3⁺%, CD4⁺%, CD8⁺%, CD4⁺/CD8⁺)] and intracranial haematoma were investigated and analysed. 

Results: After the treatment, the levels of HMGB-1 in the study group and the control group were lower than before, and the above indexes in the study group were significantly lower than those in the control group (P<0.05). The levels of GSN and GF-1 were higher than before treatment, and the above indexes in the study group were significantly better than those in the control group (P<0.05). After treatment, the NO levels in the study group and the control group were higher than that before treatment, and the above indexes in the study group were significantly better than those in the control group (P<0.05), the ET-1 level was lower than before treatment, and the above indexes in the study group were significantly lower than those in the control group (P<0.05). After treatment, the levels of CD3⁺%, CD4⁺%, CD4⁺/CD8⁺ in the study group and the control group were higher than those before treatment; the levels in the study group were significantly better than those in the control group (P<0.05), the level of CD8⁺% were lower than before treatment, and the above indexes in the study group were significantly lower than those in the control group (P<0.05). After treatment, the levels of haematoma in the study group and in the control group was lower than that before treatment, and the above indexes in the study group were significantly better than those in the control group (P<0.05). 

Conclusion: Hyperbaric oxygen can improve the symptoms of cerebral hypoxia and microcirculation, reduce intracranial pressure, inhibit the inflammatory reaction, promote the recovery of nerve cell function and the absorption of haematoma, improve the clinical symptoms of patients, and facilitate the rehabilitation of patients, which is worthy of clinical application.