Systemic immune-inflammation index in hepatocellular carcinoma patients survival outcomes: a meta-analysis

Li Yanan, Qin Jing, Li Weiwei^*

Department of emergency internal medicine, Lanzhou university second hospital, Lanzhou, Gansu, China

Objective: A meta-analysis was conducted to estimate the prognostic value of systemic immune-inflammation index (SII) for the patients with HCC.

Methods: The databases including PubMed, the Cochrane Library, and EMBASE were searched to identify the studies relevant to the association between SII and survival outcomes published up to November 30, 2019. STATA SE 12.0 was used to perform the meta-analysis.

Results: A total of 9 studies involving 2271 HCC patients were included to evaluate the prognostic value of SII in HCC patients. The resuls of our meta-analysis showed that greater SII than cutoff values predicted a poorer OS (pooled HR=1.80, 95%CI: 1.53~2.11, P=0.000). Subgroup analysis by Ethnicity illustrated that patients with a higher SII also had a worse overall survival for Asian (pooled HR=1.79, 95%CI: 1.52~2.12, P=0.000), and Caucasian (pooled HR=1.79, 95%CI: 1.53~2.10, P=0.013). The result of meta-analysis also showed that higher SII associated with worse TTR (HR=1.98, 95%CI: 1.59~2.46, P=0.000).

Conclusion: High SII may be a novel and reliable prognostic factor for HCC patients with worse OS and TTR.