RECURRENT GUILLAIN BARRÉ SYNDROME AFTER ADMINISTRATION OF INFLUENZA VACCINE. CASES REPORTS AND UPDATE OF LITERATURE DATA

Mihaela Lungu^*, Anca Telehuz, Elena Niculeţ, Carina Doina Voinescu, Eva Maria Elkan, Angel Trifan, Corina Manole Palivan, Violeta Şapira

Clinical Emergency Hospital of Galaţi, Romania; Faculty of Medicine and Pharmacy, University, Dunărea de Jos”, Galaţi, Romania

Introduction: Guillain Barré syndrome - GBS after Influenza vaccination is a rare clinical condition, estimated in the literature as having an incidence of 1.7 cases per one million vaccinations. However, although in most cases a casual relationship between vaccination and acute Guillain Barré polyradiculoneuritis could not be clear demonstrated, the results of various studies show that Influenza vaccination may be associated with GBS.

Materials and methods: In the following we present a miniseries of two cases in which GBS was triggered at an interval between 1 and 3 months postvaccination in patients who did not present any of the clinical situations known in literature as triggers of GBS. One of the patients also had an episode of relapse that complicated the treatment.

Results: Even if GBS after Influenza vaccine is a very rare condition, the result of our presentation is that the acute polyradiculoneuritis in our patients may be determined by the administration of tetravalent vaccine.

Conclusions: In none of our cases there where no others associated personal pathological conditions that could have triggered GBS, the only association being Influenza vaccination.