PLASMA FIBRINOGEN, LIPOPROTEIN A, AND D-DIMER IN PREDICTING THE OCCURRENCE OF COMPLICATED CORONARY HEART DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND THE PROGNOSIS OF PATIENTS

Mei Liu^{1, *}, Tianyun Han², Dongqian Xie²

¹Department of Rehabilitation Medicine, The No.2 Hospital of Baoding, Baoding 071000, Hebei Province, China - ²Department of Pharmacy, The No.2 Hospital of Baoding, Baoding 071000, Hebei Province, China

Aim: This study aims to explore the roles of plasma fibrinogen (FIB), lipoprotein a (Lp (A)), and D-dimer (D-D) in predicting the occurrence of complicated coronary heart disease (CHD) in patients with type 2 diabetes mellitus (T2DM) and the prognosis of patients. 

Methods: We enrolled 86 patients with T2DM (the control group, CG) and 72 patients with T2DM complicated by CHD (the observation group, OG) admitted to our hospital over the same period in this study. We tested the concentrations of FIB, D-D, and Lp (A) in the two groups of patients to analyze their correlations with cardiac troponin (cTn) and their value in predicting the occurrence of CHD in patients with T2DM. We also tested the concentrations of FIB, D-D, and Lp (A) in patients before and after treatment to explore their value in predicting the disease recurrence and assessing the prognosis of patients. 

Results: We detected higher concentrations of FIB, D-D, and Lp (A) in OG than in CG (P<0.05). FIB, D-D, and Lp (A) levels were positively correlated with cTn in OG (P<0.05). FIB, D-D, and Lp (A) all showed good efficiency in predicting the occurrence of CHD in patients with T2DM, especially when the three genes were jointly tested. In OG, levels of FIB, D-D, and Lp (A) were lower after treatment than before treatment (P<0.05), and lower in patients without recurrence than in patients with recurrence (P<0.05). 

Conclusion: FIB, D-D, and Lp (A) are highly expressed in patients with T2DM complicated by CHD. FIB, D-D, Lp (A) levels can be used to predict the occurrence and progression of CHD in patients with T2DM, which are expected to become accurate markers for CHD.