META ANALYSIS OF THE VALUE OF ULTRASONOGRAPHY COMBINED WITH NANO CARBON IN THE DETECTION OF AXILLARY SENTINEL LYMPH NODES IN BREAST CANCER

Danfeng Xu¹, Yan Zhang², Haixin Guo¹, Shunlan Liu¹, Zhirong Xu¹, Wanhong Xu^{1, *}

¹Department of Ultrasound,the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian, PR China - ²Department of Ophthalmology, the Second Affiliated Hospital of Fujian Medical University

Objective: to systematically evaluate the feasibility of sentinel lymph node biopsy (SLN) in patients with lymph node positive breast cancer after neoadjuvant chemotherapy (NAC). 

Methods: the full-text databases of PubMed, Cochrane Library, Springer, Elsevier, national technical, Wanfang and other journals were searched by computer. The literatures of sentinel lymph node biopsy in breast cancer patients after neoadjuvant chemotherapy were included. The retrieval time was from January 2000 to December 2013. The literatures that met the inclusion criteria were analyzed by meta analysis. 

Results: totally 10 clinical studies were included and 1437 patients were included. The sensitivity of sentinel lymph node biopsy was 0.867 (95% confidence interval: 0.835-0.894), and the specificity was 1.000 (95% confidence interval: 0.988-1.000). 

Conclusion: sentinel lymph node biopsy after neoadjuvant chemotherapy for breast cancer patients with positive axillary lymph nodes has high sensitivity, specificity, feasibility and accuracy.