CORRELATION OF SERUM PTX3 LEVEL WITH NEUTROPHIL PERCENTAGE, CAT SCORE, CRP LEVEL AND DISEASE SEVERITY IN PATIENTS WITH AECOPD

Lvfei Bian¹, Yang Yang², Qiuju Zhao^{2, *}

¹Department of Respiration, Zhuji People’s Hospital of Zhejiang Province, Zhuji, PR China - ²Department of Respiration, The Second People’s Hospital of Lianyungang, Jiangsu Province, Lianyungang, PR China

Objective: To study the correlation of serum pentraxins 3 (PTX3) level with neutrophil percentage, CAT score, CRP level, and disease severity in patients with AECOPD. 

Methods: The basic clinical data of 50 patients with AECOPD admitted to our hospital from February 2014 to February 2015 were retrospectively analyzed as the observation group, and they were divided into light, medium, severe, and extremely severe groups according to the results of pulmonary function tests. Twenty healthy people who met the condition of similar age and other basic information to the patient group were selected as the control group. Early morning fasting serum PTX3 levels, neutrophil percentage, CAT score, and CRP levels were recorded, and the differences in the indicators were compared in the two groups. The differences in indicators of the observation group at different degrees of illness were analyzed, and the correlations between serum PTX3 levels and neutrophil percentages, CAT scores, CRP levels, and disease severity in patients with AECOPD were studied. 

Results: The levels of serum PTX3, neutrophil percentage, and CRP levels in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05); with the forced expiratory volume in the first second as a percentage of the expected value (FEV1%) decreased, the patients’ PTX3 level, neutrophil percentage, CAT score, and CRP level gradually increased, and the differences were statistically significant (P<0.05). Pearson correlation analysis showed that the serum PTX3 level was positively correlated with neutrophil percentage (N%), CAT score, and CRP levels of AECOPD patients (P<0.05) and negatively correlated with FEV1% (P<0.05). 

Conclusion: Serum PTX3 levels in patients with AECOPD were significantly increased, and increased PTX3 may be involved in the inflammatory response of AECOPD. The serum PTX3 level is positively correlated with the percentage of neutrophils, CAT score, CRP level, and disease severity, which can be used as a clinical indicator to evaluate the severity of AECOPD patients.