THE EFFECT OF TRABECULECTOMY COMBINED WITH CO-AXIAL MICRO-INCISION PHACOEMULSIFICATION ON THE OCULAR SURFACE AND TEAR SP CONTENT IN PATIENTS WITH GLAUCOMA

Jianshu Yuan^*, Yuwin Wang, Xiaoping Xu, Pengyun Wang

Department of Ophthalmology, Ningbo Eye Hospital, Ningbo, PR China

Objective: To investigate the effect of trabeculectomy combined with coaxial microincision phacoemulsification on the content of SP in eyes and tears of glaucoma patients with cataract. 

Methods: From January 2013 to December 2016, 100 patients (119 eyes) with glaucoma complicated with cataract diagnosed by history, clinical manifestation, and related diagnosis were randomly divided into a control group and an observation group. Simple trabeculectomy was performed in the control group, and trabeculectomy combined with coaxial microincision phacoemulsification was performed in the observation group. All patients were followed for 12 months. Before 1 week, 1 month, 6 months, and 12 months after operation, the visual acuity of the two groups was examined by international standard visual acuity table, intraocular pressure was measured by Topcon tonometer, ocular surface function score was recorded, and SP content in tears was measured by enzyme-linked immunosorbent assay (Elisa). The complications of the two groups were observed and recorded, and the curative effect was recorded 12 months after operation. 

Results: There was no significant difference in the success rate of operation between the two groups (P> 0.05). At 1 day, 1 week, and 6 months after operation, the visual acuity of the observation group was significantly better than that of the control group, and there was significant difference between the two groups (P<0.001). There was no significant difference in intraocular pressure between the two groups one day after operation (P>0.05). At 1 week and at 6 months after operation, the intraocular pressure of the observation group was significantly lower than that of the control group, and there was significant difference between the two groups (P<0.001). At 1 day, 1 week, and 6 months after operation, the eye surface score and tear SP content in the observation group were significantly lower than those in the control group, and there was significant difference between the two groups (P<0.001). There were no serious postoperative complications and no significant difference in the incidence of minor complications between the two groups (P>0.05).

Conclusion: Trabeculectomy combined with coaxial microincision phacoemulsification is effective in the treatment of glaucoma complicated with cataract. It can significantly reduce the eye surface score and increase the content of SP in tears.