EFFECT OF YIQI YANGYIN HUATAN RECIPE COMBINED WITH XELOX CHEMOTHERAPY ON IMMUNE FUNCTION IN PATIENTS WITH COLORECTAL CANCER SURGERY

Xiao Cheng^*, Cao Bo, Li Meiling, Li Ke, Wang Ziming, Zhang Xiao

The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine (Guiyang 550001, Guizhou Province)

Objective: To observe the efficacy of Yiqi Yangyin Huatan Recipe in colorectal cancer patients during postoperative chemotherapy. 

Methods: Sixty patients with colorectal cancer surgery were randomly divided into control group and experimental group according to the serial number generated by rand function. The control group was treated with conventional chemotherapy regimen after colorectal cancer surgery, while the experimental group was given Yiqi Yangyin Huatan Recipe on the basis of chemotherapy-based treatment. 

Results: The experimental group treated with Yiqi Yangyin Huatan Recipe had superior QOL (quality of life assessment) and KPS (functional status) than the control group treated with chemotherapy alone (P<0.05). In terms of immune function: In the evaluation of T lymphocyte subsets before and after the experiment, comparison between the experimental group and the control group and intra-group comparison of the experimental group showed that CD4⁺, CD4⁺/CD8⁺, and CD3⁺ significantly increased (P<0.05), and CD8+ showed a comparative advantage of significant decrease (P<0.05), with significant improvement in immune function. In comparison of general data (age, gender) and change in body weight, performance of the experimental group and the control group showed no comparative significance (P>0.05). 

Conclusion: Yiqi Yangyin Huatan Recipe can improve post-chemotherapy immune function and quality of life QOL during chemotherapy of colorectal cancer patients, which provides theoretical support for clinical application of Yiqi Yangyin Huatan Recipe in postoperative chemotherapy of colorectal cancer surgery.