CORRELATION OF SERUM TIMPS AND MMPS WITH CARDIAC STRUCTURE AND FUNCTIONAL PARAMETERS IN PATIENTS WITH ESSENTIAL HYPERTENSION

He Li^{1, #}, Zhen Chen^{2, #}, Jiu Jiang^{3, *}

¹Department of Cardiovascular, Huai’an TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Huai’an, PR China - ²Department of Cardiology, Xuzhou Central Hospital, Xuzhou, PR China - ³Department of Cardiology, Lianshui County People's Hospital, Huai’an, PR China

Objective: To analyze the correlation between serum tissue inhibitors of metalloproteinase (TIMPs), matrix metalloproteinases (MMPs), and cardiac structural and functional parameters in patients with primary hypertension. 

Methods: This study was performed with the approval of the hospital ethics committee. One hundred and thirty-six patients with primary hypertension – who were treated at our hospital from September 2017 to March 2019 – were randomly selected. Levels of TIMP-1 less than 180 ng/ml were the TIMP-1 normal group (89 cases) and the levels greater than 200 ng/ml were the TIMP-1 elevated group (47 cases). Levels of MMP-9 less than 150ng/ml were normal MMP-9 groups (87 cases), and levels higher than 150ng/ml were the elevated MMP-9 group (49 cases). A cardiac-function tester was used to detect the level of each cardiac structural index [ventricular septal thickness (IVSTd) and left atrial inner diameter (LAD)] and cardiac function index [E peak/A peak velocity ratio of diastolic function (E/A), left ventricular ejection fraction (LVEF)] in each group. The Pearson correlation test was used to analyze the correlation between serum TIMPs, MMPs, and cardiac structure and function indexes in patients with primary hypertension. 

Results: In comparison to the normal TIMP-1 group, the IVSTd and LAD levels of the patients in elevated TIMP-1 group were significantly increased (P<0.05) and the levels of E/A and LVEF were significantly decreased; these differences were statistically significant (P<0.05). Compared with the normal MMP-9 group, the IVSTd and LAD levels of the patients in the elevated MMP-9 group were significantly increased (P<0.05), the levels of E/A and LVEF were significantly decreased, and the differences were statistically significant (P<0.05). According to the Pearson correlation test, the levels of TIMP-1 and MMP-9 were clearly positively correlated with cardiac structural indicators such as IVSTd and LAD, but were negatively correlated with cardiac functional indicators such as E/A and LVEF (P<0.05). 

Conclusion: The serum MMP-9 and TMIP-1 levels are abnormal in patients with hypertension and are closely related to the occurrence, development, and prognosis of arteriosclerotic disease in center and peripheral arterial hypertension patients.