CORRELATION OF SERUM CD147 AND PCⅢ EXPRESSION LEVELS WITH THE PROGRESSION OF HYPERTENSIVE LEFT VENTRICULAR HYPERTROPHY

Changguo Chen, Yijin Wang, Jimin He^*

Department of Cardiovascular Disease, Yunnan Traditional Chinese Medicine Hospital, Kunming, PR China

Objective: To study the correlation between the expression levels of serum extracellular matrix metalloproteinase-inducing factor (CD147) and procollagen type III (PCIII) and the progression of hypertensive left ventricular hypertrophy. 

Methods: Eighty-six hypertension cases who were treated in the Department of Cardiovascular Medicine of our hospital from May 2017 to March 2019 were randomly selected as research subjects. The participants were divided into simple essential hypertension groups (38 cases) and hypertension combined with left ventricular hypertrophy group (48 cases) based on whether the patients had left ventricular hypertrophy. At the same time, 40 cases who underwent health examinations in our hospital were selected as a normal control group. The expression levels of serum CD147 and PCⅢ, levels of high-sensitivity C-reactive protein (hs-CRP), platelets (PLT), white blood cells (WBC), N-terminal brain sodium-titanium precursor (NT-proBNP) and the changes of left ventricular end-diastolic dimension (LVEDD), interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular mass index (LVMI), and relative left ventricular wall thickness (RWT) in each group were measured. The correlation between serum CD147 and PCⅢ expression levels and the progression of hypertensive left ventricular hypertrophy was analysed by Pearson correlation test. 

Results: Compared with the normal control group, the levels of serum CD147, PCⅢ, log (NT-proBNP), PLT, LVMI and RWT were significantly increased in the simple essential hypertension group (P<0.05). Compared with the single essential hypertension group, serum CD147, PCⅢ, log (NT-proBNP), hs-CRP, PLT, WBC, LVMI, LVEDD, IVST, LVPWT and RWT levels were significantly higher in the hypertension combined with left ventricular hypertrophy group (P<0.05). There was no significant difference in hs-CRP, WBC, LVEDD, IVST, and LVPWT levels between the normal control group and the simple essential hypertension group (P > 0.05). According to Pearson correlation analysis, the result showed that serum CD147 and PCⅢ levels were significantly positively correlated with log (NT-proBNP), PLT, LVMI, and RWT (P<0.05). 

Conclusion: Serum CD147 and PCⅢ levels in patients with hypertensive left ventricular hypertrophy are significantly increased, and the expression levels are related to the progression of hypertensive left ventricular hypertrophy.