CASE REPORT OF PYLORIC OBSTRUCTION CAUSED BY GLYPHOSATE HERBICIDES

Yingli Ren^{1, 2}, Xiangdong Jian^{1, *}, Zhongchen Zhang¹, Qiong Ning¹, Baotian Kan^{3, *}, Li Kong²

¹Department of Poisoning and Occupational Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University,Jinan, Shandong, China - ²Department of Intensive Care Medicine, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine,

Jinan, Shandong, China - ³Department of Geriatric Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China

Background: Glyphosate has gradually replaced paraquat as one of the most commonly used herbicides, but its safety has also been questioned. 

Case presentation: Several cases of severe upper airway and digestive tract stenosis were found in patients with glyphosate herbicide poisoning. One case underwent partial gastrectomy and reconstruction of the gastric outflow tract, and one case underwent gastrostomy. Some typical cases were reported. 

Conclusions: We found that the damage of digestive tract was due to the strong acid added by some glyphosate herbicides (PH=2). The digestive tract injury in patients taking this herbicide is often very serious, and the prognosis is poor. The effective treatment measures include fasting, gastrointestinal decompression, inhibition of gastric acid secretion, protection of gastric mucosa, maintenance of electrolyte balance, parenteral nutrition, haemostasis and transfusion for gastrointestinal bleeding. Partial gastrectomy and gastric outflow tract reconstruction can be performed after the patients reach the surgical indications.