Analysis on the correlation of plasma fibrinogen, lipoprotein (a), and D-dimer with disease state and prognosis of patients with coronary heart disease

Mei Liu^1*, Tianyun Han², Dongqian Xie²

¹Department of Rehabilitation Medicine, The No.2 Hospital of Baoding, Baoding 071000, Hebei Province, China - ²Department of Pharmacy, The No.2 Hospital of Baoding, Baoding 071000, Hebei Province, China

Introduction: To analyze the correlation of plasma fibrinogen (FIB), lipoprotein (a) ((Lp (a)), and D-dimer with disease state and prognosis of patients with coronary heart disease (CHD).

Methods: Altogether 148 patients with CHD in our hospital were selected and assigned to a research group (res group), and 150 healthy individuals who received physical examination in our hospital were selected and assigned to a control group (con group). The levels of FIB, Lp (a), and D-Dimer between the two groups was compared, and the correlation of them with disease development and prognosis of patients with CHD was analyzed.

Results: The levels of FIB, Lp (a), and D-Dimer in the res group were greatly higher than those in the con group (all P<0.05), and the levels of them in patients with acute myocardial infarction were greatly higher than those in patients with unstable angina pectoris or stable angina pectoris (all P<0.05). Additionally, the levels of FIB, Lp (a), and D-Dimer in patients in stage III (according to Canadian Cardiovascular Society classification (CCSC)) were greatly higher than those in patients in stage II or stage I (all P < 0.05). In the res group, the angina pectoris grade was positively linked to FIB (r=0.53, P<0.05), Lp (a) (r=0.68, P<0.05), as well as D-Dimer (r=0.70, P<0.05), and Gensini score was also positively related to FIB (r=0.44, P<0.05), Lp (a) (r=0.47, P<0.05), as well as D-Dimer (r=0.43, P<0.05). In addition, the levels of FIB, Lp (a), and D-Dimer in the major adverse cardiovascular event (MACE) group were greatly higher than those in the non-MACCE group (all P<0.05), and the prognosis of patients was negatively linked to FIB (r=-0.64, P<0.05), Lp(A) (r=-0.73, P<0.05), as well as D-Dimer (r=-0.45, P<0.05).

Conclusion: The levels of FIB, Lp (a), and D-Dimer in patients suffering from CHD increase significantly, and the levels of them are positively related to the disease state of the patients, and negatively correlated with the prognosis of them, so FIB, Lp (a) and D-Dimer can be adopted to predict the disease development and prognosis of patients with CHD.