THE EFFICACY OF TRIMEBUTINE MALEATE COMBINED WITH WULING CAPSULE IN TREATING PATIENTS WITH GASTROINTESTINAL DISORDERS AND THE IMPACT ON PLASMA GASTROINTESTINAL HORMONES MTL, GAS AND SS

Baoqing Liu¹, Xing Jin², Chuanbiao Zhou^1*

¹Division of General Surgery, Zhejiang Hospital, Hangzhou310000, China - ²Department of Hepatopancreatobiliary Surgery, The first affiliated hospital of Fujian medical university, Fuzhou 350000, China

Objective: To determine the efficacy of trimebutine maleate combined with Wuling Capsule in treating patients with gastrointestinal disorders, and to analyze the impact on the levels of plasma gastrointestinal hormones including motilin (MTL), gastrin (GAS) and somatostatin (SS). 

Study Design: An experimental study.

Place and Duration of Study: The Department of Endocrinology ,Shangluo Central Hospital, Shaanxi Province, China, from January 2017 to February 2018.

Methodology: A total of 100 patients with gastrointestinal disorders were randomly divided into a control group and an observation group, with 50 cases in each group. Control group was treated with trimebutine maleate and observation group was treated with the combination of trimebutine maleate plus Wuling Capsule. Clinical efficacy, Treatment Emergent Symptom Scale (TESS), levels of MTL, GAS, and SS were compared.

Results: At the end of the 4th week of treatment, the total effective rate of observation group was higher than that of control group(p=0.003); MTL and GAS levels in observation group were lower than those in control group (both p<0.001), and SS level was higher than control group (p=0.043). There was no significant difference in TESS scores between the two groups at the end of the 1st week to the 4th week of treatment (p=0.798, 0.736, 0.729 and 0.428, respectively). 

Conclusion: The combination of trimebutine maleate and Wuling Capsule had good clinical efficacy in treating patients with gastrointestinal disorders, which was probably because the combination could regulate the secretion of gastrointestinal hormones MTL,GAS and SS. This combination is safe and reliable, and worthy of application and promotion.