STREM-1, CTRP5 AND SST2 ARE NEGATIVELY CORRELATED WITH THE LUNG FUNCTION OF PATIENTS

Naizhi Wang¹, Tao Feng¹, Ruiqing Wang¹, Qin Liu^2*

¹Department of Respiratory Medicine, Shengli Oilfield Central Hospital, Dongying, PR China - ²Department of Intensive Care Unit, Shengli Oilfield Central Hospital, Dongying, PR China

Objective: The objective of this study was to analyse the differences in serum soluble myeloid cell trigger receptor 1 (sTREM-1), complement C1q tumour necrosis factor-related protein 5 (CTRP5), and soluble human matrix lysin 2 (sST2) levels in patients with chronic obstructive pulmonary disease (COPD) and their clinical significance. 

Methods: A total of 96 patients admitted to the Department of Respiratory Medicine at our hospital with COPD from July 2017 to December 2018 were enrolled. Among them, 48 patients with acute and aggravated symptoms formed the exacerbation group, and 48 patients at the stable stage constituted the stable group. A further 48 patients were selected as the control group; these patients underwent physical examination at our hospital and were healthy. The changes in the sTREM-1, CTRP5, and sST2 levels of the patients in the three groups were detected using enzyme-linked immunosorbent assay (ELISA). Meanwhile, the lung function of the patients in the three groups was measured, including [1s forced expiratory volume occupational vital capacity percentage (FEV1/FVC), where the first s of exerted expiratory volume accounted for changes in the percentage of values (FEV1% pred)], and correlations between changes in sTREM-1, CTRP5, and sST2 factor levels and lung function were analysed. 

Results: The levels of serum sTREM-1, CTRP5, and sST2 in the COPD exacerbation patients were significantly higher than those in both the patients in the COPD stable group and the patients in the normal control group (P<0.01). The levels of serum sTREM-1, CTRP5, and sST2 in the patients in the COPD stable group were significantly higher than those in the patients in the normal control group (P<0.01); the levels of FEV1/FVC and FEV1%pred in the patients in the COPD exacerbation group were significantly lower than those in both the patients in the COPD stable group and the patients in the normal control group (P<0.01). The levels of FEV1/FVC and FEV1%pred in the patients in the COPD stable group were significantly higher than those in the patients in the normal control group (P<0.01). Pearson correlation analysis showed that serum levels of sTREM-1, CTRP5, and sST2 in both the patients in the COPD stable group and the patients in the COPD exacerbation group were negatively correlated with the patients’ lung function as assessed through FEV1/FVC, FEV1%pred, and COPD assessment test (CAT) scores but exhibited no significant correlation with the patients’ age, gender, or body mass index. 

Conclusion: Levels of sTREM-1, CTRP5, and sST2 are significantly elevated in the serum of patients with COPD, and levels of these three factors gradually increase with the severity of the disease, which is significantly negatively correlated with the lung function of patients. It can be used as a clinical index to evaluate the prognosis of patients with COPD.