IL-10 CHANGES IN CHILDREN WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS AFTER VITAMIN D SUPPLEMENTATION

Boyu Wang¹, Jinxiu Bai¹, Chunhui Liu¹, Hao Jia¹, Limin Chu^{2, *}

¹Department of Pediatric, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China - ²Department of Pediatric, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China

Objective: ITo study the changes of serum IL-10 levels in children with recurrent upper respiratory tract infections after vitamin D supplementation. 

Methods: 52 children with recurrent upper respiratory tract infections were randomly divided into 2 groups. The treatment group received conventional treatment combined with vitamin D supplementation. The control group received conventional treatment combined with placebo supplementation. All child patients were followed up for 12 months. The changes in serum 25-hydroxyvitamin D levels and serum IL-10 levels were examined before and after treatment. 

Results: Compared with the control group, serum IL-10 levels and 25-hydroxyvitamin D levels were significantly increased in the experimental group, and the number of respiratory infections was significantly decreased. During the one year follow-up, the serum 25-hydroxyvitamin D levels in the experimental group were positively correlated with the serum IL-10 levels. 

Discussion: Vitamin D supplementation helps to reduce the number of recurrent upper respiratory infections, which may be associated with increased IL-10 production.