IGF2 EXPRESSION CAN BE A NEW INDEX IN THE DIAGNOSIS AND PROGNOSIS OF THYROID CARCINOMA

Di Lv, Wei Ding^*

Department of Thyroid and Breast Surgery, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, PR China

Objective: TTo investigate the expression of IGF2 in papillary thyroid carcinoma and its correlation with clinical pathology. 

Methods: 47 specimens of thyroid papillary carcinoma and 32 of normal thyroid tissues were collected from March 2012 to June 2013 in our hospital. The expression of IGF2 in thyroid papillary carcinoma and normal thyroid tissues was detected by immunohistochemistry and the relationship between its expression and clinical pathology was further analysed. 

Results: The positive expression rate of IGF2 in the thyroid papillary carcinoma was 64.21% (30/47), compared with 25.81% (8/32) in the normal thyroid tissue was The expression of IGF2 in the patients with papillary carcinoma was related to the tumour diameter, lymph node metastasis and AJCC stage (P<0.05). It was not related to age (P>0.05). The 5-year survival rate of patients with high expression of IGF2 was 10.00% (3/30), which was significantly shorter than that of patients with low expression of IGF2 who had a 5-year survival rate of 47.06% (8/17). 

Conclusion: IGF2 is highly expressed in papillary thyroid carcinoma, and its expression level is related to tumour diameter, lymph node metastasis and AJCC stage of thyroid papillary carcinoma. IGF2 expression can be seen as a new index in the diagnosis and prognosis of papillary thyroid carcinoma.