EFFECTS OF LINEZOLID ON DYNAMIC BALANCE BETWEEN ANTI-INFLAMMATORY AND PRO-INFLAMMATORY FACTORS, T LYMPHOCYTE SUBSETS AND IMMUNOGLOBULINS IN PATIENTS WITH SEVERE PNEUMONIA

Jing Huang^{1, 2, #, *}, Jiquan Guo^{3, 4, #}, Xiaoling Zou^{1, 2}, Yongmei Fu⁵, Jiaxin Zhu^{1, 2}, Tiantuo Zhang^{1, 2}

¹Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, PR China - ²Institute of Respiratory Diseases, Sun Yat-sen University, Guangzhou, PR China - ³Department of Pulmonary and Critical Care Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Guangzhou, PR China - ⁴Guangdong Provincial Geriatrics Institute, Guangzhou, PR China - ⁵Department of Emergency, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, PR China

Objective: This study investigated the effects of linezolid on the dynamic balance between anti-inflammatory and pro-inflammatory factors, T lymphocyte subsets and immunoglobulins in patients with severe pneumonia. 

Methods: A total of 84 patients with severe pneumonia treated in our hospital between July 2018 and July 2019 were randomly divided into a study group (n=42) and control group (n=42). The two groups of patients were all given basic treatments, such as oxygen inhalation, phlegm reduction, nutritional support, and maintenance of the water and electrolyte balance. The control group was treated with vancomycin, and the study group was treated with linezolid. The therapeutic effect, dynamic balance of anti-inflammatory and pro-inflammatory factors, and changes in T lymphocyte subsets and immunoglobulins were compared between the two groups of patients. 

Results: The total effective rate of the study group was 95.23%, which was significantly higher than 71.43% for the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of IL-1β and TNF-α in the study group were significantly lower than those in the control group, and the levels of TGF-β in the study group were significantly higher than those in the control group (P<0.01). After treatment, serum CD³⁺ levels and CD⁴⁺/CD⁸⁺ ratios in the study group were significantly higher than those in the control group (P<0.01). After treatment, the levels of IgA, IgM and IgG in patients in the study group were significantly higher than those in the control group (P<0.01). 

Conclusion: Linezolid has a good effect in patients with severe pneumonia. It can maintain the dynamic balance of anti-inflammatory and pro-inflammatory factors, increases the levels of T lymphocyte subsets and immunoglobulins, improves immune function and enhances the cure rate.