EFFECTS OF DEXMEDETOMIDINE ON REMIFENTANIL INDUCED HYPERALGESIA, HEMODYNAMIC CHANGES AND RESPIRATORY DEPRESSION IN PATIENTS UNDERGOING GYNECOLOGICAL LAPAROSCOPIC SURGERY

Jilin Xia¹, Chunbin Wu^{2, *}, Wei Zhou¹

¹Ankang Maternity Child Health Care Hospital, Ankang, 725000 - ²Ankang City Center Hospital, Ankang, 725000

Objective: To investigate the effects of dexmedetomidine on remifentanil-induced hyperalgesia, hemodynamic changes and respiratory depression in patients undergoing gynaecological laparoscopic surgery.

Methods: From January 2017 to April 2018, 60 patients undergoing gynaecological laparoscopic surgery in our hospital were divided into an experimental (n=30) and control (n=30) group using the random number table method. The experimental group was given 0.5 μg/kg dexmedetomidine and 1.5 μg/kg remifentanil before anaesthesia, while the control group was given the same dose of normal saline and 1.5 μg/kg remifentanil. The haemodynamics (mean arterial blood pressure, heart rate, blood oxygen saturation) and respiratory rate before anaesthesia induction (T0), before tracheal intubation (T1), during tracheal intubation (T2), after tracheal intubation (T3), before extubation (T4), during extubation (T5) and after extubation (T6) were compared between the two groups. The degree of postoperative pain and the incidence of adverse reactions were also compared between the two groups.

Results: The total effective rate of the experimental group (93.3%) was significantly higher than that of the control group (73.4%) (P<0.01). There was no significant difference in the respiratory rates of patients at T0, T1, T5 and T6 (P>0.05). The respiratory rate of patients in the experimental group at T2, T3 and T4 was significantly higher than that of the control group (P<0.05). The total effective rate of the experimental group (93.3%) was significantly higher than that of the control group (73.4%) (P<0.001). The incidence of postoperative pain in the experimental group (93.3%) was significantly lower than that of the control group (73.4%) (P<0.01). The incidence of adverse reactions in the experimental group was 10%, while the incidence of adverse reactions in the control group was 16.7%, with no significant difference between the two groups (P>0.05).

Conclusion: Dexmedetomidine can significantly improve remifentanil-induced hyperalgesia, promote hemodynamic stability, relieve postoperative respiratory depression and promote postoperative recovery.