EFFECT OF TANSHINONE IIA ON PLATELET PARAMETERS, COAGULATION FUNCTION AND BLOOD LACTATE IN PATIENTS WITH SEPSIS

Zhuye Xia^{1, #}, Yunfen He^{2, #}, Jindi Ni^{1, #}, Lijing Jiang¹, Shihong Xia¹, Qi Tong¹, Lu Zhang¹, Xiang Li^{1, *}, Guofeng Shen^{1, *}

¹Department of Intensive Care, Minhang Hospital, Fudan University, Shanghai, PR China - ²Department of Nursing, Minhang District Maternal and Child Health Hospital of Shanghai, Shanghai, PR China

Objective: To investigate the effect of tanshinone IIA on platelet parameters, coagulation function and blood lactate in patients with sepsis. 

Methods: A total of 84 individuals were randomly selected from the patients with sepsis treated in our intensive care unit (ICU) from July 2017 to March 2019 and enrolled in the study. They were randomly divided into a study group and a control group, 42 patients per group. All of them were given anti-infectious therapy and organ function support therapies. The patients in the study group were also administered a sulfotanshinone sodium injection. The clinical efficacy of the two different treatments was evaluated. The levels of platelet parameters [PTL, mean platelet volume (MPV)], coagulation function [fibrinogen (FIB), thrombin time (TT), activation partial thromboplastin time (APTT), prothrombin time (PT)], blood lactate (BLa), and immune function (CD₃⁺, CD₄⁺, CD₈⁺, CD₄⁺/CD₈⁺) were determined. 

Results: The total effective rate was 80.96% in the control group, much lower than 95.24% in the study group after treatment (P<0.05). Compared to before treatment, the level of PLT was greatly elevated, and the level of MVP was significantly reduced in both groups. Furthermore, the level of PLT was much higher, and the level of MPV was much lower in the study group than in the control group (P<0.01). The level of FIB was greatly decreased, and the levels of TT, APTT, and PT were largely increased in both groups compared to before treatment. The level of FIB was much higher, but the levels of TT, APTT, and PT were much lower in the study group than those in the control group (P<0.05). The level of BLa was significantly reduced in both groups, and it was much lower in the study group than that in the control group, compared to before treatment (P<0.01). The levels of CD₃⁺, CD₄⁺, and CD₄⁺/CD₈⁺ were greatly elevated in both groups after treatment, but the level of CD₈⁺ was significantly lessened, and the range of change was much greater in the study group (P<0.05). 

Conclusions: Treating sepsis with tanshinone IIA can greatly reduce the levels of MPV and BLa, elevate the PLT level, enhance coagulation function, improve microcirculation, and strengthen whole-body immunity, with significant efficacy and value in clinic practice.