CORRELATION BETWEEN MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN AND CORONARY HEART DISEASE

Fen Cai ^*

Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, China

Objective: To investigate the correlation between serum mixed lineage kinase domain-like protein (MLKL) level and patients with coronary heart disease (CHD). 

Methods: A total of 100 CHD patient cases were analyzed, including 30 cases of acute myocardial infarction (AMI), 35 cases of unstable angina (UA), 35 cases of stable angina (SA), and 30 normal patients. Patients were divided into four groups to determine cardiac troponin T (cTnT), myoglobin (MYO), CK-MB, serum N-terminal pro-natriuretic peptide (NT-ProBNP), total cholesterol(TCHO), triglyceride(TG), HDL-C, LDL-C, and CRP levels. MLKL level in the four groups was detected using enzyme-linked immunosorbent assay kit. Correlation between MLKL and the above indexes, CHD risk factors, and Gensini scores was analyzed. 1. MLKL level in the CHD group was higher than that in the normal control group (P<0.05). MLKL level was highest in the AMI group and lowest in the SA group. 2. Levels of cTnT and CK-MB were highest in the AMI group and lowest in the SA group (P<0.05). MYO level in the UA group was higher than that in the SA group (P<0.05). 3. Levels of cTnT and NT-ProBNP were lowest in the single-branch coronary artery disease group and highest in the triple-branch coronary artery disease group (P<0.05 for all). 4. MLKL was positively correlated with NT-ProBNP and CRP levels. 5. MLKL level was positively correlated with the Gensini score in the AMI and UA groups and had no correlation in the SA group. 

Conclusion: MLKL is related to the occurrence and lesion degree of CHD, which is of clinical significance for the diagnosis and prognosis of CHD.