ANALYSIS ON THE HEMOSTATIC EFFECT AND SAFETY OF TRANEXAMIC ACID DURING CARDIAC VALVE REPLACEMENT

Yiyan Xu¹, Mei Zhong^{*, 2}

¹Operating Theater, Linyi Central Hospital, Linyi 276400, P.R. China - ²Department of Pharmacy, Tengzhou Central People's Hospital, Zaozhuang 277599, P.R. China

Objective: Investigate the hemostatic effect of tranexamic acid in heart valve replacement and analyze the safety of the drug. 

Background: A total of 100 patients requiring cardiac valve replacement in our hospital from January 2018 to December 2018 were collected. 

Method: Among them, 45 cases of patients with the use of tranexamic acid during surgery were set as group A, and 55 cases of patients received the same treatment of group A with tranexamic acid being replaced by normal saline were set as group B. Clinical indicators of the two groups were observed. Serum hemoglobin (HB), plasma fibrinogen (FIB), prothrombin time (Pt) and activated partial thrombin time (APTT) were detected by ELISA. The adverse reactions after surgery were observed in the two groups. The amount of red cell suspension (RCS) 24h after surgery and the total amount of postoperative hospital stay were significantly lower in group A than in group B (p<0.05). 

Result: There were significant changes in HB in intra-group before and after surgery compared with that before surgery (p<0.05). During and after surgery, FIB in group A was significantly higher than that in group B (p<0.05). During and after surgery, Pt in group A was significantly lower than that in group B (p<0.05). There there were significant changes in ATTP in intra-group during and after surgery compared with that before surgery (p<0.05). The incidence of total adverse reactions in group A was significantly lower than that in group B (p<0.05). 

Conclusion: The application of tranexamic acid in heart valve replacement has good hemostatic effect, with short hospital stay and fewer adverse reactions and complications.