A study on clinical outcomes and death risk factors in adult patients with klebsiella pneumoniae septicemia

Yue-Fei Shen^1#, Ling-Yu Chen^2#, Fang He^3*

¹Department of Infectious Disease, The First People’s Hospital of Xiaoshan, Hangzhou 311201, China - ²School of Nursing, Hangzhou Medical College, Hangzhou 310036, China - ³Center of clinical laboratory, the Affiliated People's Hospital of Hangzhou Medical College, Zhejiang Provincial People’s Hospital, Hangzhou 310014, China

Introduction: Klebsiella pneumoniae is one of the most important pathogens in septicemia patients. Although new anti-infection treatment regimens have been emerging, the morbidity and mortality of Klebsiella pneumoniae septicemia remains high. Finding death risk factors is important for Klebsiella pneumoniae septicemia treatment. The present study aims to investigate related factors that affect the clinical outcomes of adult patients with Klebsiella pneumoniae septicemia.

Case Presentation: A total of 99 patients with Klebsiella pneumoniae septicemia, who were treated in our hospital from January 2014 to June 2019, were retrospectively analyzed. The clinical outcomes and clinical parameters, such as gender, age, infection site, C-reactive protein (CRP), procalcitonin (PCT), sequential organ failure assessment (SOFA), and drug sensitivity results, were analyzed. The related risk factors of deaths were analyzed by multivariate logistic regression. 

Conclusion: Our results showed that nosocomial infection, CRP and SOFA scores were correlated to deaths within 30 days (P<0.05). Thus, attention should be given on patients who have experienced nosocomial Klebsiella pneumoniae septicemia, and significantly increased CRP and SOFA scores, in order to carry out early active interventions and reduce the mortality.