THE LEVEL OF SERUM TAP, CEA CAN BE USED TO EVALUATE THE CURATIVE EFFECT OF NEOADJUVANT CHEMOTHERAPY

Yanwei Hu^*

Gastrointestinal Surgery Xingtai No.3 Hospital, 108 Steel North Road, Qiaoxi District, Xingtai 054099, China

Objective: To investigate the changes in serum tumour abnormal protein (TAP) and carcinoembryonic antigen (CEA) levels in patients with rectal cancer before and after neoadjuvant chemotherapy and its relationship with the curative effect of chemotherapy.

Methods: We retrospectively analysed 115 patients who had received neoadjuvant chemotherapy for rectal cancer. At the same time, 115 healthy people were selected. The serum CEA level was measured by radioimmunity and the serum TAP level was detected using a computerized TAP detection system. The relationship between TAP and CEA levels and chemotherapy efficacy was analysed using the receiver operator characteristic (ROC) curve.

Results: The serum TAP and CEA levels in the patients were 172.15±21.47 μm² and 37.82±6.61 ng/mL, respectively, which were significantly higher than that of the healthy subjects (82.63±10.32 μm² and 1.08±0.27 ng/mL, respectively, P<0.05]. After neoadjuvant chemotherapy, 18 cases (15.65%) had complete remission (CR), 76 cases (66.09%) had partial remission, 15 cases (13.04%) had stable disease (SD), and six cases (5.22%) had advanced (PD). The level and percentage of TAP and CEA in the CR and PR patients after chemotherapy were significantly lower than that before chemotherapy, and that in the PD patients were significantly higher after chemotherapy than before chemotherapy (P<0.05). The ROC curve analysis showed that the sensitivity, specificity, accuracy and ROC of neoadjuvant chemotherapy for rectal cancer were 92.6%, 72.6%, 92.0%, 0.724, 89.0%, 0.746, 96.4%, 70.4%, 88.0%, 0.746, 96.4%, 91.7%, 97.0% and 0.928, respectively. When the critical value of neoadjuvant chemotherapy was >21%, the critical values were 92.6%, 72.6%, 92.0% and 0.724, and the critical value of neoadjuvant chemotherapy was 92.6%, 72.6%, 92.0%, 0.724, 0.746, 96.4%, 91.7%, 97.0% and 0.928, respectively. The time of the two parameters combined was significantly higher than that of the two parameters alone (P<0.05).

Conclusion: Patients with rectal cancer have higher serum TAP and CEA levels, and the detection thereof can be used as an important index for evaluating the curative effect of neoadjuvant chemotherapy, and combined detection has better evaluation efficiency.