STUDY OF PHARMACOLOGICAL EFFECTS OF SAPONINS IN GANCAOFUZI DECOCTION BY CLASSIC ANIMAL DISEASE MODELS

Ma Yinghui, Zhang Huifeng ,Zhu Heyun, Guo Shuying, Feng Bo^* 

Jilin Medical University, 5 Jilin Srteet, Jilin, 132013, China

Gancaofuzi decoction is the traditional Chinese medicine prescription for the treatment of rheumatic diseases, which consists of R.glycyrrhizae, A. macrocephalae Rhizoma, Cinnamomum cassia Presl and Radix Aconiti Praeparata. The saponins are the main pharmacodynamics compositions in Gancaofuzi decoction for their various. In this study, analgesic, anti-inflammatory and immunomodulatory effects of the saponins components in Gancaofuzi decoction were researched through several classic animal disease models. The results showed that the saponins played a better role on anti-inflammatory and immunomodulatory. This study is of great significance for exploring the pharmacodynamics basis of traditional Chinese medicine. And the study provides a theoretical basis for further study on the compatibility mechanism of traditional Chinese medicine compound.