RELATIONSHIP BETWEEN PENTRAXIN 3 AND PREECLAMPSIA AND ITS VALUES OF EVALUATING RENAL FUNCTION IMPAIRMENT

Bibo Feng^*, Jianjun Zhai, Yu Cai

Department of Obstetric and Gynecology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China

Introduction: Preeclampsia (PE) is a special disease of pregnancy, characterized by hypertension and proteinuria. In recent years, the relationship between the inflammatory state of the body and the pathogenesis of hypertension has drawn more and more attention. Pentraxin 3 (PTX3) is a newly discovered inflammatory factor, its association with pregnancy-induced hypertension and preeclampsia has seldom been reported. The aims of this study were to investigate the relationship between serum pentraxin 3 (PTX3) and the pathogenesis of preeclampsia, its value of evaluating renal function impairment. 

Case presentation: A total of 185 cases of pregnant women with preeclampsia (PE) from 2015 to 2016 were selected as PE group (129 cases of mild PE and 56 cases of severe PE), and 216 healthy pregnant women were selected as control group. The PTX3 level was measured by ELISA methods. The correlation of PTX3 with hypersensitivity C reactive protein (hsCRP), mean arterial blood pressure (MAP), 24 h urinary protein, neutrophil ratio (NC) and creatinine (Cr) was analyzed. 

Conclusion: The levels of PTX3 and hsCRP in pregnant women were increased with the increase of blood pressure, with the statistically significant differences (P<0.05). The level of PTX3 in each group was positively correlated with MAP, NC, 24 h urinary protein and Cr (P<0.05), but the hsCRP level was only positively correlated with MAP and NC (P<0.05). PTX3 is involved in the endothelial injury process induced by PE as an inflammatory mediator, and its level is correlated with the severity of the disease. Thus, PTX3 is superior to hsCRP in the evaluation of renal impairment.