META-ANALYSIS OF THE EFFICACY OF BAILING CAPSULE IN THE TREATMENT OF CHRONIC ALLOGRAFT NEPHROPATHY

YiHe Wei, Shaoqun Chen^*

Nephrology department, Yancheng Dafeng people's Hospital, Yancheng, 224100, China

Allogeneic kidney transplantation is currently recognized as one of the effective treatments for end-stage renal disease. Chronic allograft nephropathy (CAN) usually occurs six months after kidney transplantation. Renal dysfunction is a clinical feature of CAN, which is accompanied by hypertension and proteinuria, and there is currently no effective treatment. The main ingredient of Bailing Capsule is fermented Cordyceps mycelium dry powder, which has therapeutic effects on various kidney diseases. We searched for relevant literature and finally selected five articles for inclusion in the study for meta-analysis. The results showed that compared with the control group, the condition of the Bailing Capsule test group was significantly improved. The number of cases with worsening and ineffective treatment was significantly less than that of the control group. Renal function related indicators: test group SCr (SMD -1.842, 95% CI -2.638 to -1.047 p = 0.000), BUN (SMD -0.277, 95% CI -0.482 to -0.072 p = 0.008), 24h Upro (SMD - 1.378, 95% CI -2.152 to -0.603 p = 0.000) was significantly reduced, while CCR (SMD 0.770, 95% CI 0.558-0.982 p = 000) was significantly elevated. Therefore, we can initially determine that Bailing Capsule has a good effect on CAN treatment, which can effectively improve the patient's condition, and has considerable clinical value and application prospects.