IDENTIFICATION OF POTENTIAL PATHOGENIC MECHANISMS BASED ON MULTIFACTORIAL MEDIATED DYSFUNCTION OF ORAL TUMORS

Tang Zhipeng¹, Ji Jia^{2, *}, Zhou Chen², Meng Fanchen³, Lu Ying⁴, Jiao Xiaohui⁵, Xu Yuanzhi⁶

¹Stomatology Department of the Third Affiliated Hospital of Qiqihar Medical College, Qiqihar, 161005, China - ²Stomatology Department of Qiqihar Jiahua Hospital, Qiqihar, 161005, China - ³Quality Control Office of the Third Affiliated Hospital of Qiqihar Medical College, Qiqihar, 161005, China - ⁴Biotechnology Experimental Teaching Center of the Basic Medical Sciences of Qiqihar Medical College, Qiqihar, 161005, China - ⁵Stomatology Department of the Affiliated Stomatology Hospital of Harbin Medical College, Qiqihar, 161005, China - ⁶Stomatology Department of the Third Affiliated Hospital of Qiqihar Medical College, Qiqihar, 161005, China

An oral tumor is cancer formed by abnormal hyperplasia or lesions in soft and hard tissues in the mouth. The clinical manifestations are oral ulcers, and severe oral tumors can threaten life and health. At present, people do not understand the pathogenesis of multi-factor-mediated oral cancer. Therefore, based on a comprehensive strategy, we explore multi-factorially driven oral tumor pathogenesis and potential therapeutic targets. Based on the gene expression profile matrix of oral tumors, we constructed an interaction network for the specific expression of proteins in the oral tissues of patients, and thus identified a dysfunction module. Those specifically expressed proteins often play an important role in oral tumors. The internal drive gene in the protein subnet best characterizes the molecular mechanism of oral tumors, and it is a potential core molecule. Based on the predictor analysis of regulators, we identified a series of ncRNAs and transcription factors that have possible regulatory effects on oral tumors. These pivotal regulators are an essential component of the manipulation module network genes. Overall, based on a comprehensive functional block analysis, we identified proteins, and their interactions expressed explicitly in the patient's oral tissues. The regulation of potential drugs and the pharmacological effects of binding to biological targets also provide a valuable reference for drug developers to conduct drug relocation studies.