EFFECTS OF LIGNET COMBINED WITH MECOBALAMINE ON NERVE CONDUCTION VELOCITY, CLINICAL SYMPTOM AND SIGN SCORE AND CLINICAL EFFICACY IN PATIENTS WITH DIABETIC PERIPHERAL NEUROPATHY

Qiang Li^1#, Xiaoli Shen^2#, Xuejiao Wang², Ning Fan², Lina Huang^3*

¹Department of Ophthalmology, Shenzhen People's Hospital Affiliated to Jinan University, 2nd Clinical Medical College of Jinan University, Shenzhen, PR China - ²Shenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Shenzhen University School of Medicine, Shenzhen, PR China - ³Shenzhen Aier Eye Hospital, Shenzhen, PR China

Objective: To investigate the effects of daglidene combined with mecobalamin on nerve conduction velocity, clinical symptom and sign score and clinical efficacy in patients with diabetic peripheral neuropathy. 

Method: We randomly selected 88 cases of patients with diabetic peripheral neuropathy from the Department of Secretion in our hospital and randomly divided them into a research group (n = 44) and a control group (n = 44). The control group underwent a cobalt amine solution treatment; the team used a Glenn net joint cobalt amine solution treatment. The two groups were compared before and after treatments along the lines of nerve conduction velocity and clinical symptoms and signs scores. 

Results: Before treatment, there were no significant differences in MNCV and SNCV of median nerve and common peroneal nerve between the two groups (P>0.05). After treatment, MNCV and SNCV of median nerve and common peroneal nerve in the two groups were significantly higher than they were before treatment, and MNCV and SNCV of median nerve and common peroneal nerve in the study group were significantly higher than in the control group, with a statistically significant difference (P<0.01). Before treatment, there was no significant difference in TCSS scores between the two groups (P>0.05). After treatment, the TCSS scores of the two groups were significantly lower than before treatment, and the TCSS score of the study group was significantly lower than that of the control group, with a statistically significant difference (P<0.01). The total effective rate of the study group was 93.18%; this rate was significantly higher than that of the control group (75.00%) and the difference was statistically significant (P<0.05).

Conclusion: Daglidene combined with mecobalamin can improve nerve conduction velocity and clinical symptoms and signs in patients with DPN. This approach also has a strong treatment effect.