CORRELATION BETWEEN SERUM CTRP9 LEVEL AND BLOOD PRESSURE, BLOOD GLUCOSE, LDL AND INSULIN RESISTANCE IN PATIENTS WITH PRIMARY HYPERTENSION

Guoyao Zang^{1, *}, Dabo Jin², Lijuan Huang¹

¹Department of General Practice, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China - ²Hangzhou Quancheng Medical Center, Hangzhou, PR China

Objective: To study the correlation between serum CTRP9 level and blood pressure, blood glucose, LDL and insulin resistance in patients with primary hypertension. 

Methods: A test group enrolled 120 patients with primary hypertension who underwent cardiovascular medicine in our hospital from August 2018 to August 2019. Sixty healthy people in the physical examination centre of our hospital were selected as the control group in the same period. The venous blood samples from the two groups were taken, and the differences of serum C1q/TNF-related protein 9 (CTRP9), blood pressure, blood glucose, LDL and insulin resistance between the two groups were detected and compared. The correlation between serum CTRP9 level and blood pressure, blood glucose, LDL and insulin resistance in patients with primary hypertension was studied. 

Results: The systolic blood pressure, diastolic blood pressure, mean arterial pressure, insulin resistance index, fasting plasma glucose (FPG), LDL and serum hs-CRP levels in the test group were higher than those in the control group (P<0.05 or <0.01). The serum level of CTRP9 in patients in the test group was lower than that in the control group (P<0.01). There was no significant difference in serum HDL levels between the two groups (P>0.05). The levels of the insulin resistance index (HOMA-IR) and serum hs-CRP in hypertension grade 1 group were lower than those in the hypertension grade 2, and the levels in the hypertension grade 2 group were lower than in the hypertension grade 3 group (P<0.05 or <0.01). The level of serum CTRP9 in patients with hypertension grade 1 was higher than that in hypertension grade 2 group, the level in the hypertension grade 2 group was higher than the hypertension grade 3 group, (P<0.01). Pearson correlation analysis showed that serum CTRP9 was negatively correlated with mean arterial pressure, fasting blood glucose, LDL, HOMA-IR, and hs-CRP (P<0.05 or 0.01). 

Conclusion: Serum CTRP9 levels in patients with primary hypertension are lower than those in healthy people and negatively correlated with blood pressure, blood glucose, LDL and insulin resistance.