ANALYSIS OF THE APPLICATION VALUE OF VANCOMYCIN DRUG DELIVERY SYSTEM IN THE TREATMENT OF PATIENTS WITH RELATED BONE INFECTION AFTER INTERNAL FIXATION OF FEMORAL FRACTURE

Yang Liu¹, Zhifu Li², Fei Wang¹, Zhiming Cui^{1, *}

¹Department of Orthopaedics, The Second Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, People's Republic of China - ²Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, 450052, Henan, People's Republic of China

Objective: To investigate the application value of vancomycin drug delivery system in the treatment of patients with related bone infection after internal fixation of femoral fracture. 

Material and Methods: 37 patients admitted to our hospital from April 2017 to April 2019 who received vancomycin drug delivery system were selected as the research group (RG). 39 patients only received routine antibiotic therapy as control group (CG). The recovery of bone infection and skeleton of patients were compared between the two groups. 

Results: The clearance rate of bone infection, reoperation rate and fracture rehabilitation time in the RG were lower than those in the CG (p<0.050), while hip joint function, rehabilitation and bone mineral density (BMD) were higher than those in the CG (p<0.050). Multivariate results showed that age, both fracture, non-first injury and reoperation were independent risk factors affecting the rehabilitation of patients. Vancomycin slow-release drug therapy was independent protective factor affecting the rehabilitation of patients (p<0.050).

Conclusions: Vancomycin drug delivery system can effectively improve the clearance rate of bone infection, accelerate the recovery of fracture and improve the bone health of patients to a certain extent for the treatment of bone infection after internal fixation of femoral fracture. It has great application prospect in clinic in the future.