STUDY ON THE CORRELATION OF SERUM STREM-1 WITH TNF-Α AND IL-6 IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Min Meng, Yichen Wu#, Qing Chang

Department of Emergency, The Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, PR China

Objective: To analyse the correlation between serum soluble triggering receptor expressed on myeloid cell-1 (sTREM-1) and tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in patients with chronic obstructive pulmonary disease (COPD). 

Methods: Ninety-four COPD patients were randomly selected from March 2017 to September 2018. According to their condition, they were divided into acute stage (48 patients) or stable stage (46 patients). At the same time, 45 healthy subjects who came to our hospital for physical examination were selected as the control group. Serum levels of sTREM-1, TNF-α and IL-6 as well as lung function index – first second forced expiratory volume (FEV1), forced vital capacity (FVC) and ratio of FEV1 to FVC (FEV1/ FVC) – were measured. BODE index was used to evaluate the severity of COPD and comprised body mass index (BMI), airflow obstruction degree (FEV1), modified Medical Research Council (mMRC) dyspnoea scale and six-minute walk test (6MWT). The correlation of serum sTREM-1 with TNF-α and IL-6 was analysed by Speason correlation test in patients with COPD. 

Results: Compared with the control group, the serum levels of sTREM-1, TNF-α and IL-6 in acute and stable COPD patients were significantly higher (P<0.05), and the serum levels of sTREM-1, TNF-α and IL-6 in acute COPD patients were significantly higher than those in stable COPD patients (P<0.05). Compared with the control group, the levels of FVC, FEV1 and FEV1/FVC in acute and stable COPD patients were significantly lower, and the indexes of pulmonary function in acute COPD patients were significantly lower than those in stable COPD patients (P<0.05). The levels of BODE index BMI, FEV1 and MMRC in acute and stable stage patients were significantly higher than those in the control group, and the levels of 6MWT were significantly lower. The levels of BODE index BMI, FEV1 and MMRC in acute stage patients were significantly higher than those in stable stage patients, and 6MWT was significantly lower than that in stable stage patients (P<0.05). Speason correlation test showed that serum sTREM-1 was positively correlated with TNF-α, IL-6, BODE index and MMRC, and negatively correlated with pulmonary function index (P < 0.05). 

Conclusion: COPD, sTREM-1, TNF-α, IL-6, correlation.